Characterization of a novel RNAi yeast insecticide that silences mosquito 5-HT1 receptor genes.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
15 Dec 2023
Historique:
received: 08 09 2023
accepted: 12 12 2023
medline: 19 12 2023
pubmed: 19 12 2023
entrez: 18 12 2023
Statut: epublish

Résumé

G protein-coupled receptors (GPCRs), which regulate numerous intracellular signaling cascades that mediate many essential physiological processes, are attractive yet underexploited insecticide targets. RNA interference (RNAi) technology could facilitate the custom design of environmentally safe pesticides that target GPCRs in select target pests yet are not toxic to non-target species. This study investigates the hypothesis that an RNAi yeast insecticide designed to silence mosquito serotonin receptor 1 (5-HTR1) genes can kill mosquitoes without harming non-target arthropods. 5-HTR.426, a Saccharomyces cerevisiae strain that expresses an shRNA targeting a site specifically conserved in mosquito 5-HTR1 genes, was generated. The yeast can be heat-inactivated and delivered to mosquito larvae as ready-to-use tablets or to adult mosquitoes using attractive targeted sugar baits (ATSBs). The results of laboratory and outdoor semi-field trials demonstrated that consumption of 5-HTR.426 yeast results in highly significant mortality rates in Aedes, Anopheles, and Culex mosquito larvae and adults. Yeast consumption resulted in significant 5-HTR1 silencing and severe neural defects in the mosquito brain but was not found to be toxic to non-target arthropods. These results indicate that RNAi insecticide technology can facilitate selective targeting of GPCRs in intended pests without impacting GPCR activity in non-targeted organisms. In future studies, scaled production of yeast expressing the 5-HTR.426 RNAi insecticide could facilitate field trials to further evaluate this promising new mosquito control intervention.

Identifiants

pubmed: 38110471
doi: 10.1038/s41598-023-49799-3
pii: 10.1038/s41598-023-49799-3
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

22511

Subventions

Organisme : Department of the Army, US Army Contracting Command, Aberdeen Proving Ground, Natick Contracting Division
ID : W911QY-17-1-0002
Organisme : the Assistant Secretary of Defense for Health Affairs, through the Peer Reviewed Medical Research Program
ID : W81XWH-17-1-0294
Organisme : U.S. Army Medical Research Acquisition Activity through the PRMRP-Expansion Award
ID : W81XWH-21-2-0038
Organisme : Assistant Secretary of Defense for Health Affairs, through the Peer Reviewed Medical Research Program
ID : W81XWH-17-1-0295
Organisme : NIH-NIAID
ID : 1 R21 AI128116-01

Informations de copyright

© 2023. The Author(s).

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Auteurs

Keshava Mysore (K)

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Raclin-Carmichael Hall, 1234 Notre Dame Ave., South Bend, IN, 46617, USA.
The University of Notre Dame Eck Institute for Global Health, Notre Dame, IN, USA.

Teresia M Njoroge (TM)

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Raclin-Carmichael Hall, 1234 Notre Dame Ave., South Bend, IN, 46617, USA.
The University of Notre Dame Eck Institute for Global Health, Notre Dame, IN, USA.

Akilah T M Stewart (ATM)

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Raclin-Carmichael Hall, 1234 Notre Dame Ave., South Bend, IN, 46617, USA.
The University of Notre Dame Eck Institute for Global Health, Notre Dame, IN, USA.

Nikhella Winter (N)

Department of Life Sciences, Faculty of Science & Technology, The University of the West Indies, St. Augustine Campus, Trinidad and Tobago, Spain.

Majidah Hamid-Adiamoh (M)

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Raclin-Carmichael Hall, 1234 Notre Dame Ave., South Bend, IN, 46617, USA.
The University of Notre Dame Eck Institute for Global Health, Notre Dame, IN, USA.

Longhua Sun (L)

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Raclin-Carmichael Hall, 1234 Notre Dame Ave., South Bend, IN, 46617, USA.
The University of Notre Dame Eck Institute for Global Health, Notre Dame, IN, USA.

Rachel Shui Feng (RS)

Department of Life Sciences, Faculty of Science & Technology, The University of the West Indies, St. Augustine Campus, Trinidad and Tobago, Spain.

Lester D James (LD)

Department of Life Sciences, Faculty of Science & Technology, The University of the West Indies, St. Augustine Campus, Trinidad and Tobago, Spain.

Azad Mohammed (A)

Department of Life Sciences, Faculty of Science & Technology, The University of the West Indies, St. Augustine Campus, Trinidad and Tobago, Spain.

David W Severson (DW)

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Raclin-Carmichael Hall, 1234 Notre Dame Ave., South Bend, IN, 46617, USA.
The University of Notre Dame Eck Institute for Global Health, Notre Dame, IN, USA.
Department of Life Sciences, Faculty of Science & Technology, The University of the West Indies, St. Augustine Campus, Trinidad and Tobago, Spain.
Department of Biological Sciences, The University of Notre Dame, Notre Dame, IN, USA.

Molly Duman-Scheel (M)

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Raclin-Carmichael Hall, 1234 Notre Dame Ave., South Bend, IN, 46617, USA. mscheel@nd.edu.
The University of Notre Dame Eck Institute for Global Health, Notre Dame, IN, USA. mscheel@nd.edu.
Department of Biological Sciences, The University of Notre Dame, Notre Dame, IN, USA. mscheel@nd.edu.

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