Time-dependent homeostatic mechanisms underlie brain-derived neurotrophic factor action on neural circuitry.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
18 Dec 2023
18 Dec 2023
Historique:
received:
05
01
2023
accepted:
27
11
2023
medline:
19
12
2023
pubmed:
19
12
2023
entrez:
19
12
2023
Statut:
epublish
Résumé
Plasticity and homeostatic mechanisms allow neural networks to maintain proper function while responding to physiological challenges. Despite previous work investigating morphological and synaptic effects of brain-derived neurotrophic factor (BDNF), the most prevalent growth factor in the central nervous system, how exposure to BDNF manifests at the network level remains unknown. Here we report that BDNF treatment affects rodent hippocampal network dynamics during development and recovery from glutamate-induced excitotoxicity in culture. Importantly, these effects are not obvious when traditional activity metrics are used, so we delve more deeply into network organization, functional analyses, and in silico simulations. We demonstrate that BDNF partially restores homeostasis by promoting recovery of weak and medium connections after injury. Imaging and computational analyses suggest these effects are caused by changes to inhibitory neurons and connections. From our in silico simulations, we find that BDNF remodels the network by indirectly strengthening weak excitatory synapses after injury. Ultimately, our findings may explain the difficulties encountered in preclinical and clinical trials with BDNF and also offer information for future trials to consider.
Identifiants
pubmed: 38110605
doi: 10.1038/s42003-023-05638-9
pii: 10.1038/s42003-023-05638-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1278Subventions
Organisme : National Science Foundation (NSF)
ID : IOS-0919747
Organisme : New Jersey Commission on Brain Injury Research (NJCBIR)
ID : CBIR14IRG019
Organisme : New Jersey Commission on Brain Injury Research (NJCBIR)
ID : CBIR20IRG003
Organisme : New Jersey Commission on Brain Injury Research (NJCBIR)
ID : CBIR13FEL002
Organisme : New Jersey Commission on Brain Injury Research (NJCBIR)
ID : CBIR20FEL009
Organisme : New Jersey Commission on Brain Injury Research (NJCBIR)
ID : CBIR19FEL018
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : T32 GM008339-20
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : T32 GM008339-20
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : T32 GM008339-20
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : 1U19NS107464-01
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : 1U19NS107464-01
Organisme : U.S. Department of Education (ED)
ID : P200A150131
Organisme : University of Maryland (UMD)
ID : & Behavior Initiative Seed Grant FY18
Organisme : University of Maryland (UMD)
ID : & Behavior Initiative Seed Grant FY18
Organisme : Paul G. Allen Family Foundation
ID : 12347
Informations de copyright
© 2023. The Author(s).
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