Impact of maternal age and body mass index on the structure and function of the heart in newborns: a Copenhagen Baby Heart Study.
Body mass index
Echocardiography
Maternal age
Maternal factors
Newborn heart
Journal
BMC medicine
ISSN: 1741-7015
Titre abrégé: BMC Med
Pays: England
ID NLM: 101190723
Informations de publication
Date de publication:
18 Dec 2023
18 Dec 2023
Historique:
received:
03
05
2023
accepted:
01
12
2023
medline:
19
12
2023
pubmed:
19
12
2023
entrez:
19
12
2023
Statut:
epublish
Résumé
Maternal obesity and advanced age have been associated with an increased risk of structural congenital heart defects in the offspring. Whether these factors may also cause abnormalities in infant cardiac dimension and function is unknown. This study investigates whether maternal body mass index (BMI) and maternal age are associated with changes in left ventricular (LV) dimensions and function in the newborn. Infants enrolled in the Copenhagen Baby Heart Study (CBHS), who were born at term, and contributed with a transthoracic echocardiography (TTE) within 60 days of birth were included. The exposure variables were prepregnancy maternal BMI (kg/m The study cohort included 24,294 infants. Compared with infants in the BMI reference group, infants born to women with a BMI ≥ 25 kg/m Systematic population-based echocardiography of infants showed that a maternal prepregnancy BMI ≥ 25 kg/m April 2016, Copenhagen Baby Heart, NCT02753348 .
Sections du résumé
BACKGROUND
BACKGROUND
Maternal obesity and advanced age have been associated with an increased risk of structural congenital heart defects in the offspring. Whether these factors may also cause abnormalities in infant cardiac dimension and function is unknown. This study investigates whether maternal body mass index (BMI) and maternal age are associated with changes in left ventricular (LV) dimensions and function in the newborn.
METHODS
METHODS
Infants enrolled in the Copenhagen Baby Heart Study (CBHS), who were born at term, and contributed with a transthoracic echocardiography (TTE) within 60 days of birth were included. The exposure variables were prepregnancy maternal BMI (kg/m
RESULTS
RESULTS
The study cohort included 24,294 infants. Compared with infants in the BMI reference group, infants born to women with a BMI ≥ 25 kg/m
CONCLUSIONS
CONCLUSIONS
Systematic population-based echocardiography of infants showed that a maternal prepregnancy BMI ≥ 25 kg/m
CLINICAL TRIAL REGISTRATION
BACKGROUND
April 2016, Copenhagen Baby Heart, NCT02753348 .
Identifiants
pubmed: 38110921
doi: 10.1186/s12916-023-03207-9
pii: 10.1186/s12916-023-03207-9
doi:
Banques de données
ClinicalTrials.gov
['NCT02753348']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
499Informations de copyright
© 2023. The Author(s).
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