Association between vitamin D deficiency and post-acute outcomes of SARS-CoV-2 infection.
Hospitalization
Long COVID
Mortality
Post-COVID-19 condition
SARS-CoV-2
Vitamin D
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
19 Dec 2023
19 Dec 2023
Historique:
received:
01
08
2023
accepted:
28
11
2023
medline:
19
12
2023
pubmed:
19
12
2023
entrez:
19
12
2023
Statut:
aheadofprint
Résumé
This study aimed to investigate the association between vitamin D deficiency (VDD) and post-acute outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This retrospective study used the TriNetX research network to identify COVID-19 patients between January 1 and November 30, 2022. Patients were matched using propensity score matching (PSM) and divided into VDD (< 20 ng/mL) and control (≥ 20 ng/mL) groups. The primary outcome was a composite of post-COVID-19 condition (identified by ICD-10 code), all-cause emergency department (ED) visits, hospitalization, and death during the follow-up period (90-180 days) after the diagnosis of COVID-19. From an initial recruitment of 42,674 non-hospitalized patients with COVID-19 and known 25(OH)D status, a VDD group of 8300 was identified and propensity matched with 8300 controls. During the follow-up period, the VDD group had a higher risk of the primary outcome than did the control group [hazard ratio (HR) = 1.122; 95% confidence interval (CI) = 1.041-1.210]. The VDD group also had a higher risk of all-cause ED visits (HR = 1.114; 95% CI = 1.012-1.226), all-cause hospitalization (HR = 1.230; 95% CI = 1.105-1.369), and all-cause death (HR = 1.748; 95% CI = 1.047-2.290) but not post-COVID-19 condition (HR = 0.980; 95% CI = 0.630-1.523), individually. Among the COVID-19 patients, VDD might be associated with a higher risk of all-cause ED visits, hospitalization, and death during the post-acute phase.
Identifiants
pubmed: 38112761
doi: 10.1007/s00394-023-03298-3
pii: 10.1007/s00394-023-03298-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
Références
WHO (2023). https://covid19.who.int/ Accessed on June 19, 2023.
Wu Z, McGoogan JM (2020) Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. jama 323 (13):1239–1242
Lam ICH, Wong CKH, Zhang R, Chui CSL, Lai FTT, Li X, Chan EWY, Luo H, Zhang Q, Man KKC (2023) Long-term post-acute sequelae of COVID-19 infection: a retrospective, multi-database cohort study in Hong Kong and the UK. EClinicalMedicine 60
Wan EYF, Zhang R, Mathur S, Yan VKC, Lai FTT, Chui CSL, Li X, Wong CKH, Chan EWY, Lau CS (2023) Post-acute sequelae of COVID-19 in older persons: multi-organ complications and mortality. Journal of Travel Medicine:taad082
Davis HE, McCorkell L, Vogel JM, Topol EJ (2023) Long COVID: major findings, mechanisms and recommendations. Nat Rev Microbiol 21(3):133–146
doi: 10.1038/s41579-022-00846-2
pubmed: 36639608
pmcid: 9839201
Lai C-C, Hsu C-K, Yen M-Y, Lee P-I, Ko W-C, Hsueh P-R (2022) Long COVID: An inevitable sequela of SARS-CoV-2 infection. J Microbiol Immunol Infect
Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, Stevens JS, Cook JR, Nordvig AS, Shalev D, Sehrawat TS (2021) Post-acute COVID-19 syndrome. Nat Med 27(4):601–615
doi: 10.1038/s41591-021-01283-z
pubmed: 33753937
pmcid: 8893149
Shah W, Hillman T, Playford ED, Hishmeh L (2021) Managing the long term effects of covid-19: summary of NICE, SIGN, and RCGP rapid guideline. bmj 372
Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A (2019) Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions. Endocr Rev 40(4):1109–1151
doi: 10.1210/er.2018-00126
pubmed: 30321335
Bilezikian JP, Bikle D, Hewison M, Lazaretti-Castro M, Formenti AM, Gupta A, Madhavan MV, Nair N, Babalyan V, Hutchings N (2020) Mechanisms in endocrinology: vitamin D and COVID-19. Eur J Endocrinol 183(5):R133–R147
doi: 10.1530/EJE-20-0665
pubmed: 32755992
pmcid: 9494342
Charoenngam N, Holick MF (2020) Immunologic effects of vitamin D on human health and disease. Nutrients 12(7):2097
doi: 10.3390/nu12072097
pubmed: 32679784
pmcid: 7400911
Sassi F, Tamone C, D’Amelio P (2018) Vitamin D: nutrient, hormone, and immunomodulator. Nutrients 10(11):1656
doi: 10.3390/nu10111656
pubmed: 30400332
pmcid: 6266123
Malaguarnera L (2020) Vitamin D3 as potential treatment adjuncts for COVID-19. Nutrients 12(11):3512
doi: 10.3390/nu12113512
pubmed: 33202670
pmcid: 7697253
Seamans KM, Cashman KD (2009) Existing and potentially novel functional markers of vitamin D status: a systematic review. Am J Clin Nutr 89(6):1997S-2008S
doi: 10.3945/ajcn.2009.27230D
pubmed: 19403634
Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, Köstenberger M, Tmava Berisha A, Martucci G, Pilz S, Malle O (2020) Vitamin D deficiency 2.0: an update on the current status worldwide. Euro J Clin Nutr 74 (11):1498–1513
Lips P (2004) Which circulating level of 25-hydroxyvitamin D is appropriate? J Steroid Biochem Mol Biol 89:611–614
doi: 10.1016/j.jsbmb.2004.03.040
pubmed: 15225848
Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, Bhattoa HP (2020) Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients 12(4):988
doi: 10.3390/nu12040988
pubmed: 32252338
pmcid: 7231123
Cui A, Zhang T, Xiao P, Fan Z, Wang H, Zhuang Y (2023) Global and regional prevalence of vitamin D deficiency in population-based studies from 2000 to 2022: A pooled analysis of 7.9 million participants. Frontiers in Nutrition 10:1070808
Smaha J, Jackuliak P, Kužma M, Max F, Binkley N, Payer J (2023) Vitamin D deficiency prevalence in hospitalized patients with COVID-19 significantly decreased during the pandemic in slovakia from 2020 to 2022 which was associated with decreasing mortality. Nutrients 15(5):1132
doi: 10.3390/nu15051132
pubmed: 36904131
pmcid: 10005285
Hussein AM, Galal I, Amin M, Moshnib A, Makhlouf N, Makhlouf H, Abd-Elaal H, Kholief K, Tawab DA, Eldin KK (2022) Prevalence of vitamin D deficiency among patients attending Post COVID-19 follow-up clinic: a cross-sectional study. European Review for Medical & Pharmacological Sciences 26 (8)
di Filippo L, Frara S, Nannipieri F, Cotellessa A, Locatelli M, Rovere Querini P, Giustina A (2023) Low vitamin D levels are associated with Long COVID syndrome in COVID-19 survivors. The Journal of clinical endocrinology and metabolism
Min Y, Wei X, Peng X (2023) Letter to the Editor From Min et al:“Low Vitamin D Levels Are Associated With Long COVID Syndrome in COVID-19 Survivors”. The Journal of Clinical Endocrinology & Metabolism:dgad325
Taquet M, Luciano S, Geddes JR, Harrison PJ (2021) Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA. The Lancet Psychiatry 8(2):130–140
doi: 10.1016/S2215-0366(20)30462-4
pubmed: 33181098
Hsu W-H, Tsai Y-W, Wu J-Y, Liu T-H, Lai C-C (2023) Post-acute hospitalization and mortality of nirmatrelvir plus ritonavir for COVID-19 survivors. J Infect 86(4):e107–e110
doi: 10.1016/j.jinf.2023.02.007
pubmed: 36773894
pmcid: 9911974
Wu JY, Liu MY, Liu TH, Chuang MH, Hsu WH, Huang PY, Tsai YW, Kuo CY, Yeh CT, Lai CC (2023) Clinical efficacy of nirmatrelvir and ritonavir combination for treating diabetic patients with COVID-19. J Med Virol 95(6):e28866
doi: 10.1002/jmv.28866
pubmed: 37314228
Tsai YW, Wu JY, Liu TH, Chuang MH, Hsu WH, Huang PY, Lai CC, Tsai KT, Shiue YL (2023) Clinical effectiveness of oral antiviral agents in older patients with COVID-19 based on real-world data. J Med Virol 95(6):e28869
doi: 10.1002/jmv.28869
pubmed: 37322616
Liu TH, Huang PY, Wu JY, Chuang MH, Hsu WH, Tsai YW, Chang CC, Lai CC (2023) Clinical effectiveness of nirmatrelvir plus ritonavir in patients with COVID-19 and substance use disorders based on real-world data. J Med Virol 95(5):e28801
doi: 10.1002/jmv.28801
pubmed: 37218308
Chen YC, Ho CH, Liu TH, Wu JY, Huang PY, Tsai YW, Lai CC (2023) Long-term risk of herpes zoster following COVID-19: a retrospective cohort study of 2 442 686 patients. J Med Virol 95(4):e28745
doi: 10.1002/jmv.28745
pubmed: 37185849
TriNetX TriNetX Publication Guidelines. https://trinetx.com/real-world-resources/publications/trinetx-publication-guidelines/ .
Liu T-H, Wu J-Y, Huang P-Y, Tsai Y-W, Lai C-C (2023) The effect of nirmatrelvir plus ritonavir on the long-term risk of epilepsy and seizure following COVID-19: A retrospective cohort study including 91,528 patients. J Infect 86(3):256–308
doi: 10.1016/j.jinf.2023.01.014
pubmed: 36649824
pmcid: 9867601
Tsai Y-W, Tsai C-F, Wu J-Y, Huang P-Y, Liu T-H, Lai C-C (2023) The risk of methicillin-resistant Staphylococcus aureus infection following COVID-19 and influenza: a retrospective cohort study from the TriNetX network. J Infect 86(3):256–308
doi: 10.1016/j.jinf.2023.01.006
pubmed: 36649824
pmcid: 9867601
Amrein K, Papinutti A, Mathew E, Vila G, Parekh D (2018) Vitamin D and critical illness: what endocrinology can learn from intensive care and vice versa. Endocr Connect 7(12):R304–R315
doi: 10.1530/EC-18-0184
pubmed: 30352414
pmcid: 6240147
Haukoos JS, Lewis RJ (2015) The propensity score Jama 314(15):1637–1638
doi: 10.1001/jama.2015.13480
pubmed: 26501539
Neves FF, Pott-Junior H, de Sousa SS, Cominetti MR, de Melo Freire CC, da Cunha AF, Júnior AAJ (2022) Vitamin D deficiency predicts 30-day hospital mortality of adults with COVID-19. Clinical Nutrition ESPEN 50:322–325
doi: 10.1016/j.clnesp.2022.05.027
pubmed: 35871942
pmcid: 9195455
Jayawardena R, Jeyakumar DT, Francis TV, Misra A (2021) Impact of the vitamin D deficiency on COVID-19 infection and mortality in Asian countries. Diabetes Metab Syndr 15(3):757–764
doi: 10.1016/j.dsx.2021.03.006
pubmed: 33823331
pmcid: 7955807
Mehri A, Sotoodeh Ghorbani S, Farhadi-Babadi K, Rahimi E, Barati Z, Taherpour N, Izadi N, Shahbazi F, Mokhayeri Y, Seifi A (2023) Risk Factors Associated with Severity and Death from COVID-19 in Iran: A Systematic Review and Meta-Analysis Study. Journal of Intensive Care Medicine:08850666231166344
Jude EB, Ling SF, Allcock R, Yeap BX, Pappachan JM (2021) Vitamin D deficiency is associated with higher hospitalization risk from COVID-19: a retrospective case-control study. J Clin Endocrinol Metab 106(11):e4708–e4715
doi: 10.1210/clinem/dgab439
pubmed: 34139758
Aranow C (2011) Vitamin D and the immune system. J Investig Med 59(6):881–886
doi: 10.2310/JIM.0b013e31821b8755
pubmed: 21527855
pmcid: 3166406
Athanassiou L, Mavragani CP, Koutsilieris M (2022) The immunomodulatory properties of vitamin D. Mediterranean J Rheumatol 33(1):7
doi: 10.31138/mjr.33.1.7
Beyerstedt S, Casaro EB, Rangel ÉB (2021) COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. Eur J Clin Microbiol Infect Dis 40:905–919
doi: 10.1007/s10096-020-04138-6
pubmed: 33389262
pmcid: 7778857
Getachew B, Tizabi Y (2021) Vitamin D and COVID-19: role of ACE2, age, gender, and ethnicity. J Med Virol 93(9):5285–5294
doi: 10.1002/jmv.27075
pubmed: 33990955
pmcid: 8242434
Burgaz A, Åkesson A, Öster A, Michaëlsson K, Wolk A (2007) Associations of diet, supplement use, and ultraviolet B radiation exposure with vitamin D status in Swedish women during winter. Am J Clin Nutr 86(5):1399–1404
doi: 10.1093/ajcn/86.5.1399
pubmed: 17991652
O’Sullivan F, Laird E, Kelly D, van Geffen J, van Weele M, McNulty H, Hoey L, Healy M, McCarroll K, Cunningham C, Casey M, Ward M, Strain JJ, Molloy AM, Zgaga L (2017) Ambient UVB dose and sun enjoyment are important predictors of vitamin D status in an older population. J Nutr 147(5):858–868. https://doi.org/10.3945/jn.116.244079
doi: 10.3945/jn.116.244079
pubmed: 28331054
O'Neill CM, Kazantzidis A, Ryan MJ, Barber N, Sempos CT, Durazo-Arvizu RA, Jorde R, Grimnes G, Eiriksdottir G, Gudnason V, Cotch MF, Kiely M, Webb AR, Cashman KD (2016) Seasonal Changes in Vitamin D-Effective UVB Availability in Europe and Associations with Population Serum 25-Hydroxyvitamin D. Nutrients 8 (9). https://doi.org/10.3390/nu8090533
Holick MF (2007) Vitamin D deficiency. N Engl J Med 357(3):266–281. https://doi.org/10.1056/NEJMra070553
doi: 10.1056/NEJMra070553
pubmed: 17634462
Crowe FL, Jolly K, MacArthur C, Manaseki-Holland S, Gittoes N, Hewison M, Scragg R, Nirantharakumar K (2019) Trends in the incidence of testing for vitamin D deficiency in primary care in the UK: a retrospective analysis of The Health Improvement Network (THIN), 2005–2015. BMJ Open 9(6):e028355. https://doi.org/10.1136/bmjopen-2018-028355
doi: 10.1136/bmjopen-2018-028355
pubmed: 31167871
pmcid: 6561453
Cashman KD (2020) Vitamin D deficiency: defining, prevalence, causes, and strategies of addressing. Calcif Tissue Int 106(1):14–29. https://doi.org/10.1007/s00223-019-00559-4
doi: 10.1007/s00223-019-00559-4
pubmed: 31069443
Cashman KD, Dowling KG, Škrabáková Z, Gonzalez-Gross M, Valtueña J, De Henauw S, Moreno L, Damsgaard CT, Michaelsen KF, Mølgaard C, Jorde R, Grimnes G, Moschonis G, Mavrogianni C, Manios Y, Thamm M, Mensink GB, Rabenberg M, Busch MA, Cox L, Meadows S, Goldberg G, Prentice A, Dekker JM, Nijpels G, Pilz S, Swart KM, van Schoor NM, Lips P, Eiriksdottir G, Gudnason V, Cotch MF, Koskinen S, Lamberg-Allardt C, Durazo-Arvizu RA, Sempos CT, Kiely M (2016) Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 103(4):1033–1044. https://doi.org/10.3945/ajcn.115.120873
doi: 10.3945/ajcn.115.120873
pubmed: 26864360
pmcid: 5527850
Schleicher RL, Sternberg MR, Looker AC, Yetley EA, Lacher DA, Sempos CT, Taylor CL, Durazo-Arvizu RA, Maw KL, Chaudhary-Webb M, Johnson CL, Pfeiffer CM (2016) National Estimates of Serum Total 25-Hydroxyvitamin D and Metabolite Concentrations Measured by Liquid Chromatography-Tandem Mass Spectrometry in the US Population during 2007–2010. J Nutr 146(5):1051–1061. https://doi.org/10.3945/jn.115.227728
doi: 10.3945/jn.115.227728
pubmed: 27052537
pmcid: 4841925
Sarafin K, Durazo-Arvizu R, Tian L, Phinney KW, Tai S, Camara JE, Merkel J, Green E, Sempos CT, Brooks SP (2015) Standardizing 25-hydroxyvitamin D values from the Canadian Health Measures Survey. Am J Clin Nutr 102(5):1044–1050. https://doi.org/10.3945/ajcn.114.103689
doi: 10.3945/ajcn.114.103689
pubmed: 26423385
pmcid: 4625585
Nielsen NM, Junker TG, Boelt SG, Cohen AS, Munger KL, Stenager E, Ascherio A, Boding L, Hviid A (2022) Vitamin D status and severity of COVID-19. Sci Rep 12(1):19823. https://doi.org/10.1038/s41598-022-21513-9
doi: 10.1038/s41598-022-21513-9
pubmed: 36396686
pmcid: 9672358
Chen C, Haupert SR, Zimmermann L, Shi X, Fritsche LG, Mukherjee B (2022) Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review. J Infect Dis 226(9):1593–1607. https://doi.org/10.1093/infdis/jiac136
doi: 10.1093/infdis/jiac136
pubmed: 35429399