Extraocular muscle enlargement in dysthyroid optic neuropathy.
Journal
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
ISSN: 1715-3360
Titre abrégé: Can J Ophthalmol
Pays: England
ID NLM: 0045312
Informations de publication
Date de publication:
16 Dec 2023
16 Dec 2023
Historique:
received:
11
08
2023
revised:
27
10
2023
accepted:
22
11
2023
medline:
20
12
2023
pubmed:
20
12
2023
entrez:
19
12
2023
Statut:
aheadofprint
Résumé
To investigate extraocular muscle volumes in thyroid eye disease (TED) patients with and without dysthyroid optic neuropathy (DON). Retrospective cohort study. TED patients who had computed tomography of the orbits. The extraocular muscles were manually segmented in consecutive axial and coronal slices, and the volume was calculated by summing the areas in each slice and multiplying by the slice thickness. Data were collected on patient demographics, disease presentation, thyroid function tests, and antibody levels. Imaging from 200 orbits was evaluated. The medial rectus, lateral rectus, superior muscle group, inferior rectus, and superior oblique volumes were significantly greater in orbits with DON compared with TED orbits without DON (p < 0.01 for all). There was no significant difference in the inferior oblique muscle volume (p = 0.19). Increase in volume of the superior oblique muscle showed the highest odds for DON. Each 100 m All extraocular muscle volumes except for the inferior oblique were significantly greater in DON patients. Superior oblique enlargement was associated with the highest odds of DON, suggesting superior oblique enlargement to be a novel marker of DON.
Identifiants
pubmed: 38114063
pii: S0008-4182(23)00374-5
doi: 10.1016/j.jcjo.2023.11.015
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.