Effects of donor-specific microvascular anatomy on hemodynamic perfusion in human choriocapillaris.

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
19 Dec 2023
Historique:
received: 16 05 2023
accepted: 28 11 2023
medline: 20 12 2023
pubmed: 20 12 2023
entrez: 19 12 2023
Statut: epublish

Résumé

Evidence from histopathology and clinical imaging suggest that choroidal anatomy and hemodynamic perfusion are among the earliest changes in retinal diseases such as age-related macular degeneration (AMD). However, how inner choroidal anatomy affects hemodynamic perfusion is not well understood. Therefore, we sought to understand the influences of choroidal microvascular architecture on the spatial distribution of hemodynamic parameters in choriocapillaris from human donor eyes using image-based computational hemodynamic (ICH) simulations. We subjected image-based inner choroid reconstructions from eight human donor eyes to ICH simulation using a kinetic-based volumetric lattice Boltzmann method to compute hemodynamic distributions of velocity, pressure, and endothelial shear stress. Here, we demonstrate that anatomic parameters, including arteriolar and venular arrangements and intercapillary pillar density and distribution exert profound influences on inner choroidal hemodynamic characteristics. Reductions in capillary, arteriolar, and venular density not only reduce the overall blood velocity within choriocapillaris, but also substantially increase its spatial heterogeneity. These first-ever findings improve understanding of how choroidal anatomy affects hemodynamics and may contribute to pathogenesis of retinal diseases such as AMD.

Identifiants

DOI: 10.1038/s41598-023-48631-2 PMID: 38114564
pubmed: 38114564
doi: 10.1038/s41598-023-48631-2
pii: 10.1038/s41598-023-48631-2
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

22666

Subventions

Organisme : NIH HHS
ID : R01EY031039
Pays : United States

Informations de copyright

© 2023. The Author(s).

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Auteurs

Senyou An (S)

State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering, Shenzhen University, Shenzhen, 518060, China.
Department of Mechanical and Energy Engineering, Indiana University-Purdue University, Indianapolis, IN, 46202, USA.

Huidan Yu (H)

Department of Mechanical and Energy Engineering, Indiana University-Purdue University, Indianapolis, IN, 46202, USA. whyu@iupui.edu.
Department of Vascular Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. whyu@iupui.edu.

M D Mahfuzul Islam (MDM)

Department of Mechanical and Energy Engineering, Indiana University-Purdue University, Indianapolis, IN, 46202, USA.

Xiaoyu Zhang (X)

Department of Mechanical and Energy Engineering, Indiana University-Purdue University, Indianapolis, IN, 46202, USA.

Yuting Zhan (Y)

Department of Mechanical and Energy Engineering, Indiana University-Purdue University, Indianapolis, IN, 46202, USA.
Dyson School of Design Engineering, Imperial College London, London, SW7 2AZ, UK.

Joseph J Olivieri (JJ)

Center for Advanced Vision Science, University of Virginia School of Medicine, Street, Charlottesville, VA, 22908, USA.
Department of Pathology, University of Virginia School of Medicine, Street, Charlottesville, VA, 22908, USA.

Jayakrishna Ambati (J)

Center for Advanced Vision Science, University of Virginia School of Medicine, Street, Charlottesville, VA, 22908, USA.
Department of Pathology, University of Virginia School of Medicine, Street, Charlottesville, VA, 22908, USA.
Department of Ophthalmology, University of Virginia School of Medicine, Street, Charlottesville, VA, 22908, USA.
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Street, Charlottesville, VA, 22908, USA.

Jun Yao (J)

Research Center of Multiphase Flow in Porous Media, China University of Petroleum (East China), Qingdao, 266580, China.

Bradley D Gelfand (BD)

Center for Advanced Vision Science, University of Virginia School of Medicine, Street, Charlottesville, VA, 22908, USA. gelfand@virginia.edu.
Department of Ophthalmology, University of Virginia School of Medicine, Street, Charlottesville, VA, 22908, USA. gelfand@virginia.edu.
Department of Biomedical Engineering, University of Virginia School of Medicine, Street, Charlottesville, VA, 22908, USA. gelfand@virginia.edu.

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