Multicenter development of a PET-based risk assessment tool for product-specific outcome prediction in large B-cell lymphoma patients undergoing CAR T-cell therapy.

CAR T-cell therapy Extra-nodal involvement Large B-cell lymphoma MTV Risk factors

Journal

European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988

Informations de publication

Date de publication:
Apr 2024
Historique:
received: 15 07 2023
accepted: 30 11 2023
pubmed: 20 12 2023
medline: 20 12 2023
entrez: 19 12 2023
Statut: ppublish

Résumé

The emergence of chimeric antigen receptor (CAR) T-cell therapy fundamentally changed the management of individuals with relapsed and refractory large B-cell lymphoma (LBCL). However, real-world data have shown divergent outcomes for the approved products. The present study therefore set out to evaluate potential risk factors in a larger cohort. Our analysis set included 88 patients, treated in four German university hospitals and one Italian center, who had undergone 2-[ Extra-nodal involvement emerged as the most relevant of the conventional tumor and patient characteristics. Moreover, we found that inclusion of metabolic tumor volume (MTV) further improves outcome prediction. The hazard ratio for a PFS event was 1.68 per unit increase of our proposed risk score (95% confidence interval [1.20, 2.35], P = 0.003), which comprised both extra-nodal disease and lymphoma burden. While the most suitable MTV cut-off among patients receiving tisagenlecleucel was 11 mL, a markedly higher threshold of 259 mL showed optimal predictive performance in those undergoing axicabtagene ciloleucel treatment. Our analysis demonstrates that the presence of more than one extra-nodal lesion and higher MTV in LBCL are associated with inferior outcome after CAR T-cell treatment. Based on an assessment tool including these two factors, patients can be assigned to one of three risk groups. Importantly, as shown by our study, metabolic tumor burden might facilitate CAR T-cell product selection and reflect the individual need for bridging therapy.

Identifiants

pubmed: 38114616
doi: 10.1007/s00259-023-06554-0
pii: 10.1007/s00259-023-06554-0
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1361-1370

Subventions

Organisme : German Research Foundation
ID : 451580403
Organisme : Wilhelm Sander Foundation
ID : 2018.087.1

Informations de copyright

© 2023. The Author(s).

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Auteurs

Conrad-Amadeus Voltin (CA)

Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. conrad-amadeus.voltin@uk-koeln.de.

Andrea Paccagnella (A)

Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

Michael Winkelmann (M)

Department of Radiology, University Hospital Munich, Ludwig Maximilian University Munich, Munich, Germany.

Jan-Michel Heger (JM)

Department of Internal Medicine I, Center for Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf (CIO ABCD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Cologne Lymphoma Working Group (CLWG), Cologne, Germany.

Beatrice Casadei (B)

Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
'L. e A. Seràgnoli' Institute of Hematology, Scientific Institute for Research, Hospitalization, and Healthcare (IRCCS) 'Azienda Ospedaliero-Universitaria Di Bologna', University of Bologna, Bologna, Italy.

Laura Beckmann (L)

Department of Internal Medicine I, Center for Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf (CIO ABCD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Ken Herrmann (K)

Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
German Cancer Consortium (DKTK) Partner Site Essen/Düsseldorf, Essen, Germany.

Franziska J Dekorsy (FJ)

Department of Nuclear Medicine, University Hospital Munich, Ludwig Maximilian University Munich, Munich, Germany.

Nadine Kutsch (N)

Department of Internal Medicine I, Center for Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf (CIO ABCD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Cologne Lymphoma Working Group (CLWG), Cologne, Germany.

Peter Borchmann (P)

Department of Internal Medicine I, Center for Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf (CIO ABCD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Cologne Lymphoma Working Group (CLWG), Cologne, Germany.

Stefano Fanti (S)

Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
Division of Nuclear Medicine, Scientific Institute for Research, Hospitalization, and Healthcare (IRCCS) 'Azienda Ospedaliero-Universitaria Di Bologna', University of Bologna, Bologna, Italy.

Wolfgang G Kunz (WG)

Department of Radiology, University Hospital Munich, Ludwig Maximilian University Munich, Munich, Germany.

Marion Subklewe (M)

Department of Medicine III, Comprehensive Cancer Center Munich (CCCM), University Hospital Munich, Ludwig Maximilian University Munich, Munich, Germany.
Laboratory for Translational Cancer Immunology, Gene Center Munich, Ludwig Maximilian University Munich, Munich, Germany.
German Cancer Consortium (DKTK) and Bavarian Center for Cancer Research (BZKF) Partner Site Munich, Munich, Germany.

Carsten Kobe (C)

Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Pier Luigi Zinzani (PL)

Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
'L. e A. Seràgnoli' Institute of Hematology, Scientific Institute for Research, Hospitalization, and Healthcare (IRCCS) 'Azienda Ospedaliero-Universitaria Di Bologna', University of Bologna, Bologna, Italy.

Matthias Stelljes (M)

Department of Medicine A-Hematology, Oncology, and Pneumology, West German Cancer Center (WTZ) Network Partner Site, University Hospital Münster, University of Münster, Münster, Germany.

Katrin S Roth (KS)

Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Alexander Drzezga (A)

Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Richard Noppeney (R)

German Cancer Consortium (DKTK) Partner Site Essen/Düsseldorf, Essen, Germany.
Department of Hematology and Stem Cell Transplantation, West German Cancer Center (WTZ), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Kambiz Rahbar (K)

Department of Nuclear Medicine, University Hospital Münster, University of Münster, Münster, Germany.

H Christian Reinhardt (HC)

German Cancer Consortium (DKTK) Partner Site Essen/Düsseldorf, Essen, Germany.
Department of Hematology and Stem Cell Transplantation, West German Cancer Center (WTZ), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Bastian von Tresckow (B)

German Cancer Consortium (DKTK) Partner Site Essen/Düsseldorf, Essen, Germany.
Department of Hematology and Stem Cell Transplantation, West German Cancer Center (WTZ), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Robert Seifert (R)

Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
German Cancer Consortium (DKTK) Partner Site Essen/Düsseldorf, Essen, Germany.
Department of Nuclear Medicine, University Hospital Münster, University of Münster, Münster, Germany.

Jörn C Albring (JC)

Department of Medicine A-Hematology, Oncology, and Pneumology, West German Cancer Center (WTZ) Network Partner Site, University Hospital Münster, University of Münster, Münster, Germany.

Viktoria Blumenberg (V)

Department of Medicine III, Comprehensive Cancer Center Munich (CCCM), University Hospital Munich, Ludwig Maximilian University Munich, Munich, Germany.
Laboratory for Translational Cancer Immunology, Gene Center Munich, Ludwig Maximilian University Munich, Munich, Germany.
German Cancer Consortium (DKTK) and Bavarian Center for Cancer Research (BZKF) Partner Site Munich, Munich, Germany.

Andrea Farolfi (A)

Division of Nuclear Medicine, Scientific Institute for Research, Hospitalization, and Healthcare (IRCCS) 'Azienda Ospedaliero-Universitaria Di Bologna', University of Bologna, Bologna, Italy.

Sarah Flossdorf (S)

Institute for Medical Informatics, Biometry, and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Philipp Gödel (P)

Department of Internal Medicine I, Center for Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf (CIO ABCD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Cologne Lymphoma Working Group (CLWG), Cologne, Germany.

Christine Hanoun (C)

German Cancer Consortium (DKTK) Partner Site Essen/Düsseldorf, Essen, Germany.
Department of Hematology and Stem Cell Transplantation, West German Cancer Center (WTZ), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Classifications MeSH