Discovery and verification of extracellular microRNA biomarkers for diagnostic and prognostic assessment of preeclampsia at triage.

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
22 Dec 2023
Historique:
medline: 20 12 2023
pubmed: 20 12 2023
entrez: 20 12 2023
Statut: ppublish

Résumé

We report on the identification of extracellular miRNA (ex-miRNA) biomarkers for early diagnosis and prognosis of preeclampsia (PE). Small RNA sequencing of maternal serum prospectively collected from participants undergoing evaluation for suspected PE revealed distinct patterns of ex-miRNA expression among different categories of hypertensive disorders in pregnancy. Applying an iterative machine learning method identified three bivariate miRNA biomarkers (

Identifiants

DOI: 10.1126/sciadv.adg7545 PMID: 38117879
pubmed: 38117879
doi: 10.1126/sciadv.adg7545
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadg7545

Auteurs

Robert Morey (R)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0001-8480-4564

Lara Poling (L)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-9145-7254

Srimeenakshi Srinivasan (S)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.

Carolina Martinez-King (C)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0009-0003-3618-7997

Adanna Anyikam (A)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.

Kathy Zhang-Rutledge (K)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-0534-2857

Cuong To (C)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.

Abbas Hakim (A)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-2875-4715

Marina Mochizuki (M)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.

Kajal Verma (K)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0001-9159-9722

Antoinette Mason (A)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.

Vy Tran (V)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.

Morgan Meads (M)

Department of Pathology, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-5970-7356

Leah Lamale-Smith (L)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.

Hilary Roeder (H)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.

Mariko Horii (M)

Department of Pathology, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-4996-6792

Gladys A Ramos (GA)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-9838-4991

Peter DeHoff (P)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-0163-7535

Mana M Parast (MM)

Department of Pathology, University of California, San Diego, La Jolla, CA, USA.

Priyadarshini Pantham (P)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.

Louise C Laurent (LC)

Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-2095-7534

Classifications MeSH