Adult stem cell activity in naked mole rats for long-term tissue maintenance.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
20 Dec 2023
Historique:
received: 25 03 2023
accepted: 01 12 2023
medline: 21 12 2023
pubmed: 21 12 2023
entrez: 20 12 2023
Statut: epublish

Résumé

The naked mole rat (NMR), Heterocephalus glaber, the longest-living rodent, provides a unique opportunity to explore how evolution has shaped adult stem cell (ASC) activity and tissue function with increasing lifespan. Using cumulative BrdU labelling and a quantitative imaging approach to track intestinal ASCs (Lgr5

Identifiants

pubmed: 38123565
doi: 10.1038/s41467-023-44138-6
pii: 10.1038/s41467-023-44138-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8484

Subventions

Organisme : Universiteit van Pretoria | Forestry and Agricultural Biotechnology Institute, at the University of Pretoria | DST-NRF Centre Of Excellence In Tree Health Biotechnology (DST/NRF Centre of Excellence in Tree Health Biotechnology)
ID : GUN 64756

Informations de copyright

© 2023. The Author(s).

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Auteurs

Shamir Montazid (S)

Nuffield Department of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.

Sheila Bandyopadhyay (S)

Department of Biological Sciences, Rutgers University, Newark, 07102, NJ, USA.

Daniel W Hart (DW)

Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria, 0028, Republic of South Africa.

Nan Gao (N)

Department of Biological Sciences, Rutgers University, Newark, 07102, NJ, USA.

Brian Johnson (B)

Division of Biomedical Informatics, Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, 92093, CA, USA.

Sri G Thrumurthy (SG)

Endoscopy, King's College Hospital NHS Foundation Trust, London, SE5 9RS, UK.

Dustin J Penn (DJ)

Konrad Lorenz Institute of Ethology, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine, Vienna, 1160, Austria.

Bettina Wernisch (B)

Konrad Lorenz Institute of Ethology, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine, Vienna, 1160, Austria.

Mukesh Bansal (M)

Bristol Myers Squibb, San Diego, 92121, CA, USA.

Philipp M Altrock (PM)

Department for Theoretical Biology, Max Planck Institute for Evolutionary Biology, 24306, Ploen, Germany.

Fabian Rost (F)

DRESDEN-concept Genome Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, 01307, Dresden, Germany.

Patrycja Gazinska (P)

Biobank Research Group, Lukasiewicz Research Network, PORT Polish Center for Technology Development, Wroclaw, Poland.

Piotr Ziolkowski (P)

Department of Clinical and Experimental Pathology, Wroclaw Medical University, 50-368, Wroclaw, Poland.

Bu'Hussain Hayee (B)

Endoscopy, King's College Hospital NHS Foundation Trust, London, SE5 9RS, UK.

Yue Liu (Y)

Department of Biological Sciences, Rutgers University, Newark, 07102, NJ, USA.

Jiangmeng Han (J)

Department of Biological Sciences, Rutgers University, Newark, 07102, NJ, USA.

Annamaria Tessitore (A)

Novo Nordisk Research Centre Oxford, Oxford, OX37FZ, UK.

Jana Koth (J)

Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.

Walter F Bodmer (WF)

Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK.

James E East (JE)

Translational Gastroenterology Unit, Experimental Medicine Division, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK.

Nigel C Bennett (NC)

Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria, 0028, Republic of South Africa.

Ian Tomlinson (I)

Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK. ian.tomlinson@oncology.ox.ac.uk.

Shazia Irshad (S)

Nuffield Department of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK. shazia.irshad@ndcls.ox.ac.uk.

Classifications MeSH