Caffeine and cortical excitability, as measured with paired-pulse transcranial magnetic stimulation.
SICI
caffein, threshold tracking SICI
short-interval intracortical inhibition
trancranial magnetic stimulation
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
21 Dec 2023
21 Dec 2023
Historique:
revised:
27
11
2023
received:
08
12
2022
accepted:
12
12
2023
medline:
21
12
2023
pubmed:
21
12
2023
entrez:
21
12
2023
Statut:
aheadofprint
Résumé
The transcranial magnetic stimulation tests of short-interval intracortical inhibition (SICI) by both conventional amplitude measurements (A-SICI) and threshold-tracking (T-SICI) are important methods to investigate intracortical inhibitory circuits, and T-SICI has been proposed to aid the diagnosis of amyotrophic lateral sclerosis. Beverages containing caffeine are widely consumed, and caffeine has been reported to affect cortical excitability. The aim of this study was to determine whether these SICI tests are affected by caffeine. Twenty-four healthy subjects (13 females, 11 males, aged from 19 to 31, mean: 26.2 ± 2.4 years) were studied in a single fixed-dose randomized double-blind placebo-controlled cross-over trial of 200 mg caffeine or placebo ingested as chewing gum. A-SICI and T-SICI, using parallel tracking (T-SICIp), were performed before and after chewing gum. There was no significant change in SICI parameters after placebo in A-SICI (p > .10) or T-SICIp (p > .30), and no significant effect of caffeine was found on A-SICI (p > .10) or T-SICIp (p > .50) for any of the interstimulus intervals. There is no need for caffeine abstention before measurements of SICI by either the T-SICI or A-SICI measurements.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Lundbeck Foundation
Organisme : Grosserer L. F. Foghts Fond
Organisme : Aase og Ejnar Danielsens Fond
Organisme : Dagmar Marshalls Fond
Informations de copyright
© 2023 Wiley Periodicals LLC.
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