The effects of Lactobacillus delbrueckii and Lactobacillus rhamnosus on cytokines and their related molecules: An

This study aimed to assess the This study was conducted with 20 newly diagnosed SLE patients (18 females, 2 males; mean age: 33.3±12.4 years; range, 18 to 68 years) between September 2017 and September 2018. Extracted PBMCs from each patient were divided into 4 cell groups in our study. Three cell groups act as treatment groups receiving The gene expression levels of forkhead box P3 (FOXP3), transforming growth factor beta (TGF-β), interleukin (IL)-6, IL-10, and IL-2 were evaluated by a quantitative real-time polymerase chain reaction. The results revealed that expression levels of FOXP3, TGF-β, IL-10, and IL-2 increased and the level of IL-6 decreased in probiotics-receiving groups compared to the control group. The results of the present study show that these probiotics could be effective in regulating the balance of cytokine gene expression

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Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.