Prophylactic prednisolone promotes AAV5 hepatocyte transduction through the novel mechanism of AAV5 co-receptor PDGFRα upregulation and innate immune suppression.
Journal
Human gene therapy
ISSN: 1557-7422
Titre abrégé: Hum Gene Ther
Pays: United States
ID NLM: 9008950
Informations de publication
Date de publication:
21 Dec 2023
21 Dec 2023
Historique:
medline:
21
12
2023
pubmed:
21
12
2023
entrez:
21
12
2023
Statut:
aheadofprint
Résumé
Adeno-associated virus (AAV) vectors are used to deliver therapeutic transgenes, but host immune responses may interfere with transduction and transgene expression. We evaluated prophylactic corticosteroid treatment on AAV5-mediated expression in liver tissue. Wild-type C57BL/6 mice received 6x10
Identifiants
pubmed: 38126359
doi: 10.1089/hum.2023.065
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM