Bacteriostatic cells instead of bacteriostatic antibiotics?

antibiotic mode of action bacteriostatic antibiotics bacteriostatic cells

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
21 Dec 2023
Historique:
medline: 21 12 2023
pubmed: 21 12 2023
entrez: 21 12 2023
Statut: aheadofprint

Résumé

This year we commemorate the centennial of the birth of the mature concept of bacteriostasis by John W. Churchman at Cornell University Medical School. The term bacteriostasis has primarily been applied to antibiotics (bacteriostatic antibiotics). In this Opinion paper, we are revisiting this concept by suggesting that some antibiotics are drugs that induce bacteria to become bacteriostatic. Cells that are unable to multiply, thereby preventing the antibiotic from exerting major lethal effects on them, are a variant ("different") type of cells, bacteriostatic cells. Note that the term "bacteriostasis" should not be associated only with antimicrobials but with many stressful conditions. In that respect, the drug promotion of bacteriostasis might resemble other types of stress-induced cellular differentiation, such as sporulation, in which spores can be considered "bacteriostatic cells" or perhaps as persister bacteria, which can become "normal cells" again when the stressful conditions have abated.

Identifiants

pubmed: 38126752
doi: 10.1128/mbio.02680-23
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0268023

Auteurs

Fernando Baquero (F)

Department of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain.
Public Health Networking Biomedical Research Centre in Epidemiology and Public Health (CIBERESP), Madrid, Spain.

Jerónimo Rodríguez-Beltrán (J)

Department of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain.
Public Health Networking Biomedical Research Centre in Infectious Diseases (CIBERINFEC), Madrid, Spain.

Bruce R Levin (BR)

Department of Biology, Emory University, Atlanta, Georgia, USA.

Classifications MeSH