Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition.
AGPAT2
congenital generalized lipodystrophy
inflammation
lysophosphatidic acid
phosphatidic acid
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
26 Dec 2023
26 Dec 2023
Historique:
medline:
21
12
2023
pubmed:
21
12
2023
entrez:
21
12
2023
Statut:
ppublish
Résumé
AGPAT2 (1-acyl-sn-glycerol-3-phosphate-acyltransferase-2) converts lysophosphatidic acid (LPA) into phosphatidic acid (PA), and mutations of the
Identifiants
pubmed: 38127985
doi: 10.1073/pnas.2312666120
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2312666120Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK119968
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK133143
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK045735
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124272
Pays : United States
Organisme : NIAAA NIH HHS
ID : R21 AA029457
Pays : United States
Déclaration de conflit d'intérêts
Competing interests statement:S.M. is an employee of Ionis Pharmaceuticals. G.I.S. consults for and has received research support from Ionis Pharmaceuticals; is a stockholder of Orsobio, which owns the Yale intellectual property for CRMP; is an inventor of the Yale patent for CRMP.