A non-systematic review of the features of pharmacotherapy in the elderly at the stage of taking medications.

age-related changes human organism patients pharmacodynamics pharmacokinetics risks of adverse reactions

Journal

Journal of clinical pharmacology
ISSN: 1552-4604
Titre abrégé: J Clin Pharmacol
Pays: England
ID NLM: 0366372

Informations de publication

Date de publication:
21 Dec 2023
Historique:
received: 03 04 2023
accepted: 15 12 2023
medline: 22 12 2023
pubmed: 22 12 2023
entrez: 21 12 2023
Statut: aheadofprint

Résumé

The human body is subservient to the age-related changes that affect not only the outer appearance, but also organs and tissues. They also concern the processes of pharmacokinetics and dynamics. This means that the absorption, distribution and metabolism of drugs used by an elderly patient will be slowed down. Therefore, it becomes necessary to prescribe a special dosing regimen for older people. An actual problem is also that with age, many patients require more drugs than young people. This increases the risk of side effects, because many drugs are difficult to combine with each other. Pharmacy of our time is a science that is constantly developing and modernizing, which allows changing therapy for the better: prescribing drugs in smaller quantities, with a smaller range of adverse reactions and a better effect. The aim of the work is to analyze the impact and relationship of older age on the pharmacotherapy of patients, as well as the risks of drug-induced diseases. To carry out this work, such research methods as analysis, synthesis, comparative analysis, classification, analogy, abstraction, induction and generalization were used. The features of the stages of pharmacokinetics and pharmacodynamics in the elderly were considered; studied the data of clinical studies, literature in geriatrics; the effects of a combination or increase in the dosage of drugs have been noted. After the collection of research data and the analysis, it turned out that it is real and necessary to avoid the negative consequences of pharmacotherapy in elderly and senile patients. Considering the natural age-related changes in the condition and functioning of organs and systems, constantly monitoring the effectiveness of drugs and undesirable reactions of the body to them, adjusting treatment protocols will have a favorable result and help optimize pharmacotherapy for the elderly, reduce the risk of side effects and diseases caused by medications. This article is protected by copyright. All rights reserved.

Identifiants

pubmed: 38129179
doi: 10.1002/jcph.2399
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

This article is protected by copyright. All rights reserved.

Auteurs

Lyudmila Yermukhanova (L)

Department of Public Health and Health Care, West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan.

Kerbez Kimatova (K)

Department of Public Health and Health Care, West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan.

Rysty Nazarbayeva (R)

Department of Evidence-Based Medicine and Scientific Management, West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan.

Zhanar Dostanova (Z)

Center of Nursing Excellence, West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan.

Gulshara Aimbetova (G)

Department of Public Health, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan.

Classifications MeSH