Muscle diffusion MRI reveals autophagic buildup in a mouse model for Pompe disease.

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
20 Dec 2023
Historique:
received: 29 08 2023
accepted: 14 12 2023
medline: 22 12 2023
pubmed: 22 12 2023
entrez: 21 12 2023
Statut: epublish

Résumé

Quantitative muscle MRI is increasingly important in the non-invasive evaluation of neuromuscular disorders and their progression. Underlying histopathotological alterations, leading to changes in qMRI parameters are incompletely unraveled. Early microstructural differences of unknown origin reflected by Diffusion MRI in non-fat infiltrated muscles were detected in Pompe patients. This study employed a longitudinal approach with a Pompe disease mouse model to investigate the histopathological basis of these changes. Monthly scans of Pompe (Gaa

Identifiants

DOI: 10.1038/s41598-023-49971-9 PMID: 38129558
pubmed: 38129558
doi: 10.1038/s41598-023-49971-9
pii: 10.1038/s41598-023-49971-9
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

22822

Subventions

Organisme : Deutsche Gesellschaft für Muskelkranke
ID : GU1/2
Organisme : Medizinische Fakultät, Ruhr-Universität Bochum
ID : FoRUM F960R-2020
Organisme : NWO-AES
ID : 18929
Organisme : Deutsche Forschungsgemeinschaft
ID : 122679504 - TPA5

Informations de copyright

© 2023. The Author(s).

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Auteurs

Marlena Rohm (M)

Department of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Heimer Institute for Muscle Research, BG-University Hospital Bergmannsheil gGmbH, 44789, Bochum, Germany.

Gabriele Russo (G)

Department of Neurophysiology, Medical Faculty, Ruhr-University Bochum, 44801, Bochum, Germany.

Xavier Helluy (X)

Department of Neurophysiology, Medical Faculty, Ruhr-University Bochum, 44801, Bochum, Germany.
Department of Biopsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr-University Bochum, 44801, Bochum, Germany.

Martijn Froeling (M)

Department of Radiology, University Medical Centre Utrecht, 3584 CX, Utrecht, The Netherlands.

Vincent Umathum (V)

Institute of Neuropathology, Justus Liebig University, 35390, Giessen, Germany.
Institute of Pathology and Molecular Pathology, Bundeswehrkrankenhaus Ulm, 89081, Ulm, Germany.

Nicolina Südkamp (N)

Department of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Heimer Institute for Muscle Research, BG-University Hospital Bergmannsheil gGmbH, 44789, Bochum, Germany.

Denise Manahan-Vaughan (D)

Department of Neurophysiology, Medical Faculty, Ruhr-University Bochum, 44801, Bochum, Germany.

Robert Rehmann (R)

Department of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.

Johannes Forsting (J)

Department of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.

Frank Jacobsen (F)

Department of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Heimer Institute for Muscle Research, BG-University Hospital Bergmannsheil gGmbH, 44789, Bochum, Germany.

Andreas Roos (A)

Department of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Heimer Institute for Muscle Research, BG-University Hospital Bergmannsheil gGmbH, 44789, Bochum, Germany.
Department of Neuropediatrics, University Hospital Essen, Duisburg-Essen University, 47057, Essen, Germany.

Yoon Shin (Y)

Molecular Genetic and Metabolism Laboratory, 80333, Munic, Germany.
University Children's Hospital, 80333, Munich, Germany.

Anne Schänzer (A)

Institute of Neuropathology, Justus Liebig University, 35390, Giessen, Germany.

Matthias Vorgerd (M)

Department of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Heimer Institute for Muscle Research, BG-University Hospital Bergmannsheil gGmbH, 44789, Bochum, Germany.

Lara Schlaffke (L)

Department of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany. lara.schlaffke@rub.de.
Heimer Institute for Muscle Research, BG-University Hospital Bergmannsheil gGmbH, 44789, Bochum, Germany. lara.schlaffke@rub.de.

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