Modeling clothing as a secondary source of exposure to SVOCs across indoor microenvironments.
Journal
Journal of exposure science & environmental epidemiology
ISSN: 1559-064X
Titre abrégé: J Expo Sci Environ Epidemiol
Pays: United States
ID NLM: 101262796
Informations de publication
Date de publication:
21 Dec 2023
21 Dec 2023
Historique:
received:
27
03
2023
accepted:
28
11
2023
revised:
27
11
2023
medline:
22
12
2023
pubmed:
22
12
2023
entrez:
22
12
2023
Statut:
aheadofprint
Résumé
Evidence suggests that clothing can influence human exposure to semi-volatile organic compounds (SVOCs) through transdermal uptake and inhalation. The objectives of this study were [1] to investigate the potential for clothing to function as a transport vector and secondary source of gas-phase SVOCs across indoor microenvironments, [2] to elucidate how clothing storage, wear, and laundering can influence the dynamics of transdermal uptake, and [3] to assess the potential for multiple human occupants to influence the multimedia dynamics of SVOCs indoors. A computational modeling framework (ABICAM) was expanded, applied, and evaluated by simulating and augmenting two "real-world" chamber experiments. A primary strength of this framework was its representation of occupants and their clothing as unique entities with the potential for location changes. Estimates of transdermal uptake of diethyl phthalate (DEP) and di(n-butyl) phthalate (DnBP) were generally consistent with those extrapolated from measured concentrations of urinary metabolites, and those predicted by two other mechanistic models. ABICAM predicted that clean clothing (long sleeves, long pants, and socks, 100% cotton, 1 mm thick) readily accumulated DEP (6900-9700 μg) and DnBP (4500-4800 μg) from the surrounding chamber air over 6 h of exposure to average concentrations of 233 (DEP) and 114 (DnBP) μg·m Though the estimated secondary inhalation exposures from contaminated clothing were low compared to the corresponding primary exposures, these secondary exposures could be accentuated in other contexts, for example, involving longer timeframes of clothing storage, multiple occupants wearing contaminated clothing, and/or repeated instances of clothing-mediated transport of contaminants (e.g., from an occupational setting). This modeling study reaffirms the effectiveness of clean clothing in reducing transdermal uptake of airborne SVOCs and conversely, that contaminated clothing could be a source of SVOC exposure via transdermal uptake and by acting as a vector for transporting those contaminants to other locations.
Sections du résumé
BACKGROUND
BACKGROUND
Evidence suggests that clothing can influence human exposure to semi-volatile organic compounds (SVOCs) through transdermal uptake and inhalation.
OBJECTIVES
OBJECTIVE
The objectives of this study were [1] to investigate the potential for clothing to function as a transport vector and secondary source of gas-phase SVOCs across indoor microenvironments, [2] to elucidate how clothing storage, wear, and laundering can influence the dynamics of transdermal uptake, and [3] to assess the potential for multiple human occupants to influence the multimedia dynamics of SVOCs indoors.
METHODS
METHODS
A computational modeling framework (ABICAM) was expanded, applied, and evaluated by simulating and augmenting two "real-world" chamber experiments. A primary strength of this framework was its representation of occupants and their clothing as unique entities with the potential for location changes.
RESULTS
RESULTS
Estimates of transdermal uptake of diethyl phthalate (DEP) and di(n-butyl) phthalate (DnBP) were generally consistent with those extrapolated from measured concentrations of urinary metabolites, and those predicted by two other mechanistic models. ABICAM predicted that clean clothing (long sleeves, long pants, and socks, 100% cotton, 1 mm thick) readily accumulated DEP (6900-9700 μg) and DnBP (4500-4800 μg) from the surrounding chamber air over 6 h of exposure to average concentrations of 233 (DEP) and 114 (DnBP) μg·m
SIGNIFICANCE
CONCLUSIONS
Though the estimated secondary inhalation exposures from contaminated clothing were low compared to the corresponding primary exposures, these secondary exposures could be accentuated in other contexts, for example, involving longer timeframes of clothing storage, multiple occupants wearing contaminated clothing, and/or repeated instances of clothing-mediated transport of contaminants (e.g., from an occupational setting).
IMPACT
CONCLUSIONS
This modeling study reaffirms the effectiveness of clean clothing in reducing transdermal uptake of airborne SVOCs and conversely, that contaminated clothing could be a source of SVOC exposure via transdermal uptake and by acting as a vector for transporting those contaminants to other locations.
Identifiants
pubmed: 38129669
doi: 10.1038/s41370-023-00621-2
pii: 10.1038/s41370-023-00621-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.
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