Risk of newly developed atrial fibrillation by alcohol consumption differs according to genetic predisposition to alcohol metabolism: a large-scale cohort study with UK Biobank.
Alcohol consumption
Atrial fibrillation
Genetic predisposition to disease
Prognosis
Journal
BMC medicine
ISSN: 1741-7015
Titre abrégé: BMC Med
Pays: England
ID NLM: 101190723
Informations de publication
Date de publication:
21 Dec 2023
21 Dec 2023
Historique:
received:
04
08
2023
accepted:
13
12
2023
medline:
22
12
2023
pubmed:
22
12
2023
entrez:
22
12
2023
Statut:
epublish
Résumé
The predictive relationship between mild-to-moderate alcohol consumption and the risk of incident atrial fibrillation (AF) remains controversial. We investigated whether the relationship between alcohol consumption and the risk of incident AF could be associated with the genetic predisposition to alcohol metabolism. A total of 399,329 subjects with genetic data from the UK Biobank database, enrolled between 2006 and 2010, were identified and followed for incident AF until 2021. Genetic predisposition to alcohol metabolism was stratified according to the polygenic risk score (PRS) tertiles. Alcohol consumption was categorized as non-drinkers, mild-to-moderate drinkers (< 30 g/day), and heavy drinkers (≥ 30 g/day). During the follow-up (median 12.2 years), 19,237 cases of AF occurred. When stratified by PRS tertiles, there was a significant relationship between genetic predisposition to alcohol metabolism and actual alcohol consumption habits (P < 0.001). Mild-to-moderate drinkers showed a decreased risk of AF (HR 0.96, 95% CI 0.92-0.99), and heavy drinkers showed an increased risk of AF (HR 1.06, 95% CI 1.02-1.10) compared to non-drinkers. When stratified according to PRS tertiles for genetic predisposition to alcohol metabolism, mild-to-moderate drinkers had equivalent AF risks, and heavy drinkers showed increased AF risk in the low PRS tertile group. However, mild-to-moderate drinkers had decreased AF risks and heavy drinkers showed similar risks of AF in the middle/high PRS tertile groups. Differential associations between alcohol consumption habits and incident AF across genetic predisposition to alcohol metabolism were observed; individuals with genetic predisposition to low alcohol metabolism were more susceptible to AF.
Sections du résumé
BACKGROUND
BACKGROUND
The predictive relationship between mild-to-moderate alcohol consumption and the risk of incident atrial fibrillation (AF) remains controversial.
OBJECTIVE
OBJECTIVE
We investigated whether the relationship between alcohol consumption and the risk of incident AF could be associated with the genetic predisposition to alcohol metabolism.
METHODS
METHODS
A total of 399,329 subjects with genetic data from the UK Biobank database, enrolled between 2006 and 2010, were identified and followed for incident AF until 2021. Genetic predisposition to alcohol metabolism was stratified according to the polygenic risk score (PRS) tertiles. Alcohol consumption was categorized as non-drinkers, mild-to-moderate drinkers (< 30 g/day), and heavy drinkers (≥ 30 g/day).
RESULTS
RESULTS
During the follow-up (median 12.2 years), 19,237 cases of AF occurred. When stratified by PRS tertiles, there was a significant relationship between genetic predisposition to alcohol metabolism and actual alcohol consumption habits (P < 0.001). Mild-to-moderate drinkers showed a decreased risk of AF (HR 0.96, 95% CI 0.92-0.99), and heavy drinkers showed an increased risk of AF (HR 1.06, 95% CI 1.02-1.10) compared to non-drinkers. When stratified according to PRS tertiles for genetic predisposition to alcohol metabolism, mild-to-moderate drinkers had equivalent AF risks, and heavy drinkers showed increased AF risk in the low PRS tertile group. However, mild-to-moderate drinkers had decreased AF risks and heavy drinkers showed similar risks of AF in the middle/high PRS tertile groups.
CONCLUSIONS
CONCLUSIONS
Differential associations between alcohol consumption habits and incident AF across genetic predisposition to alcohol metabolism were observed; individuals with genetic predisposition to low alcohol metabolism were more susceptible to AF.
Identifiants
pubmed: 38129845
doi: 10.1186/s12916-023-03229-3
pii: 10.1186/s12916-023-03229-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
509Subventions
Organisme : Seoul National University Hospital
ID : 04-2022-2260
Informations de copyright
© 2023. The Author(s).
Références
Chugh SS, Havmoeller R, Narayanan K, et al. Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation. 2014;129:837–47.
doi: 10.1161/CIRCULATIONAHA.113.005119
pubmed: 24345399
Adderley NJ, Ryan R, Nirantharakumar K, Marshall T. Prevalence and treatment of atrial fibrillation in UK general practice from 2000 to 2016. Heart. 2019;105:27–33.
doi: 10.1136/heartjnl-2018-312977
pubmed: 29991504
Tsao CW, Aday AW, Almarzooq ZI, et al. Heart disease and stroke statistics-2022 update: a report from the American Heart Association. Circulation. 2022;145:e153–639.
doi: 10.1161/CIR.0000000000001052
pubmed: 35078371
Lip GY, Nieuwlaat R, Pisters R, Lane DA, Crijns HJ. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation. Chest. 2010;137:263–72.
doi: 10.1378/chest.09-1584
pubmed: 19762550
Hindricks G, Potpara T, Dagres N, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42:373–498.
doi: 10.1093/eurheartj/ehaa612
pubmed: 32860505
Colilla S, Crow A, Petkun W, Singer DE, Simon T, Liu X. Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population. Am J Cardiol. 2013;112:1142–7.
doi: 10.1016/j.amjcard.2013.05.063
pubmed: 23831166
Krijthe BP, Kunst A, Benjamin EJ, et al. Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060. Eur Heart J. 2013;34:2746–51.
doi: 10.1093/eurheartj/eht280
pubmed: 23900699
pmcid: 3858024
Asad Z, Abbas M, Javed I, Korantzopoulos P, Stavrakis S. Obesity is associated with incident atrial fibrillation independent of gender: a meta-analysis. J Cardiovasc Electrophysiol. 2018;29:725–32.
doi: 10.1111/jce.13458
pubmed: 29443438
Aune D, Schlesinger S, Norat T, Riboli E. Tobacco smoking and the risk of atrial fibrillation: a systematic review and meta-analysis of prospective studies. Eur J Prev Cardiol. 2018;25:1437–51.
doi: 10.1177/2047487318780435
pubmed: 29996680
Qureshi WT, Alirhayim Z, Blaha MJ, et al. Cardiorespiratory fitness and risk of incident atrial fibrillation: results from the Henry Ford Exercise Testing (FIT) Project. Circulation. 2015;131:1827–34.
doi: 10.1161/CIRCULATIONAHA.114.014833
pubmed: 25904645
Park CS, Choi EK, Kyung D, et al. Physical activity changes and the risk of incident atrial fibrillation in patients with type 2 diabetes mellitus: a nationwide longitudinal follow-up cohort study of 1.8 million subjects. Diabetes Care. 2023;46:434–40.
doi: 10.2337/dc22-1655
pubmed: 36469745
Park CS, Han KD, Choi EK, et al. Lifestyle is associated with atrial fibrillation development in patients with type 2 diabetes mellitus. Sci Rep. 2021;11:4676.
doi: 10.1038/s41598-021-84307-5
pubmed: 33633333
pmcid: 7907194
Whitman IR, Agarwal V, Nah G, et al. Alcohol abuse and cardiac disease. J Am Coll Cardiol. 2017;69:13–24.
doi: 10.1016/j.jacc.2016.10.048
pubmed: 28057245
pmcid: 5226115
Goncalves A, Claggett B, Jhund PS, et al. Alcohol consumption and risk of heart failure: the atherosclerosis risk in communities study. Eur Heart J. 2015;36:939–45.
doi: 10.1093/eurheartj/ehu514
pubmed: 25602025
pmcid: 4481602
Voskoboinik A, Prabhu S, Ling LH, Kalman JM, Kistler PM. Alcohol and atrial fibrillation: a sobering review. J Am Coll Cardiol. 2016;68:2567–76.
doi: 10.1016/j.jacc.2016.08.074
pubmed: 27931615
Csengeri D, Sprunker NA, Di Castelnuovo A, et al. Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes. Eur Heart J. 2021;42:1170–7.
doi: 10.1093/eurheartj/ehaa953
pubmed: 33438022
pmcid: 7982286
Di Castelnuovo A, Costanzo S, Bonaccio M, et al. Moderate alcohol consumption is associated with lower risk for heart failure but not atrial fibrillation. JACC Heart Fail. 2017;5:837–44.
doi: 10.1016/j.jchf.2017.08.017
pubmed: 29032141
Gallagher C, Hendriks JML, Elliott AD, et al. Alcohol and incident atrial fibrillation - A systematic review and meta-analysis. Int J Cardiol. 2017;246:46–52.
doi: 10.1016/j.ijcard.2017.05.133
pubmed: 28867013
Walters RK, Polimanti R, Johnson EC, et al. Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci. 2018;21:1656–69.
doi: 10.1038/s41593-018-0275-1
pubmed: 30482948
pmcid: 6430207
Harada S, Agarwal DP, Goedde HW. Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. Lancet. 1981;2:982.
doi: 10.1016/S0140-6736(81)91172-7
pubmed: 6117742
Yukawa Y, Muto M, Hori K, et al. Combination of ADH1B*2/ALDH2*2 polymorphisms alters acetaldehyde-derived DNA damage in the blood of Japanese alcoholics. Cancer Sci. 2012;103:1651–5.
doi: 10.1111/j.1349-7006.2012.02360.x
pubmed: 22703580
pmcid: 7659228
Yamashita T, Arima Y, Hoshiyama T, et al. Effect of the ALDH2 variant on the prevalence of atrial fibrillation in habitual drinkers. JACC Asia. 2022;2:62–70.
doi: 10.1016/j.jacasi.2021.10.009
pubmed: 36340257
pmcid: 9627901
Sudlow C, Gallacher J, Allen N, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12:e1001779.
doi: 10.1371/journal.pmed.1001779
pubmed: 25826379
pmcid: 4380465
Bycroft C, Freeman C, Petkova D, et al. The UK Biobank resource with deep phenotyping and genomic data. Nature. 2018;562:203–9.
doi: 10.1038/s41586-018-0579-z
pubmed: 30305743
pmcid: 6786975
Lim KX, Rijsdijk F, Hagenaars SP, et al. Studying individual risk factors for self-harm in the UK Biobank: a polygenic scoring and Mendelian randomisation study. PLoS Med. 2020;17:e1003137.
doi: 10.1371/journal.pmed.1003137
pubmed: 32479557
pmcid: 7263593
Chang CC, Chow CC, Tellier LC, Vattikuti S, Purcell SM, Lee JJ. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience. 2015;4:7.
doi: 10.1186/s13742-015-0047-8
pubmed: 25722852
pmcid: 4342193
Dawson DA, Goldstein RB, Saha TD, Grant BF. Changes in alcohol consumption: United States, 2001–2002 to 2012–2013. Drug Alcohol Depend. 2015;148:56–61.
doi: 10.1016/j.drugalcdep.2014.12.016
pubmed: 25620731
Hong JW, Noh JH, Kim DJ. The prevalence of and factors associated with high-risk alcohol consumption in Korean adults: the 2009–2011 Korea National Health and Nutrition Examination Survey. PLoS One. 2017;12:e0175299.
doi: 10.1371/journal.pone.0175299
pubmed: 28384270
pmcid: 5383276
World Health Organization. Management of Substance Abuse Team. Global status report on alcohol and health. Geneva: World Health Organization; 2014.
O’Keefe JH, Bybee KA, Lavie CJ. Alcohol and cardiovascular health: the razor-sharp double-edged sword. J Am Coll Cardiol. 2007;50:1009–14.
Albert MA, Glynn RJ, Ridker PM. Alcohol consumption and plasma concentration of C-reactive protein. Circulation. 2003;107(3):443–7.
doi: 10.1161/01.CIR.0000045669.16499.EC
pubmed: 12551869
Greenfield JR, Samaras K, Hayward CS, Chisholm DJ, Campbell LV. Beneficial postprandial effect of a small amount of alcohol on diabetes and cardiovascular risk factors: modification by insulin resistance. J Clin Endocrinol Metab. 2005;90:661–72.
doi: 10.1210/jc.2004-1511
pubmed: 15522927
Millwood IY, Walters RG, Mei XW, et al. Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China. Lancet. 2019;393:1831–42.
doi: 10.1016/S0140-6736(18)31772-0
pubmed: 30955975
pmcid: 6497989
Larsson SC, Burgess S, Mason AM, Michaelsson K. Alcohol consumption and cardiovascular disease: a Mendelian Randomization study. Circ Genom Precis Med. 2020;13:e002814.
doi: 10.1161/CIRCGEN.119.002814
pubmed: 32367730
pmcid: 7299220
Biddinger KJ, Emdin CA, Haas ME, et al. Association of habitual alcohol intake with risk of cardiovascular disease. JAMA Netw Open. 2022;5:e223849.
doi: 10.1001/jamanetworkopen.2022.3849
pubmed: 35333364
pmcid: 8956974
Edenberg HJ, Foroud T. Genetics of alcoholism. Handb Clin Neurol. 2014;125:561–71.
doi: 10.1016/B978-0-444-62619-6.00032-X
pubmed: 25307596
Zhou H, Kalayasiri R, Sun Y, et al. Genome-wide meta-analysis of alcohol use disorder in East Asians. Neuropsychopharmacology. 2022;47:1791–7.
doi: 10.1038/s41386-022-01265-w
pubmed: 35094024
pmcid: 9372033
Ge J, Han W, Ma C, et al. Association of acetaldehyde dehydrogenase 2 rs671 polymorphism with the occurrence and progression of atrial fibrillation. Front Cardiovasc Med. 2022;9:1027000.
doi: 10.3389/fcvm.2022.1027000
pubmed: 36426220
pmcid: 9679000