Macrophage polarization in inflammatory bowel disease.
Immunotherapy
Inflammatory bowel disease
Macrophage
Polarization
Signaling pathway
Journal
Cell communication and signaling : CCS
ISSN: 1478-811X
Titre abrégé: Cell Commun Signal
Pays: England
ID NLM: 101170464
Informations de publication
Date de publication:
21 Dec 2023
21 Dec 2023
Historique:
received:
16
06
2023
accepted:
04
11
2023
medline:
22
12
2023
pubmed:
22
12
2023
entrez:
22
12
2023
Statut:
epublish
Résumé
The growing prevalence of inflammatory bowel disease (IBD) has encouraged research efforts, which have contributed to gradual improvements in our understanding of IBD diagnosis and therapeutic approaches. The pathogenesis of IBD has not been fully elucidated; however, the combined actions of environmental, genetic, immune factors, and microbial organisms are believed to cause IBD. In the innate immune system, macrophages play important roles in maintaining intestinal health and in the development of IBD. Macrophages can be polarized from M0 into several phenotypes, among which M1 and M2 play critical roles in IBD development and the repair of intestinal homeostasis and damage. Certain macrophage-related IBD studies already exist; however, the functions of each phenotype have not been fully elucidated. As technology develops, understanding the link between macrophages and IBD has increased, including the growing knowledge of the developmental origins of intestinal macrophages and their performance of comprehensive functions. This review describes macrophage polarization in IBD from the perspectives of macrophage development and polarization, macrophage changes in homeostasis and IBD, metabolic changes, and the mechanisms of macrophage polarization in IBD. The discussion of these topics provides new insights into immunotherapy strategies for IBD. Video Abstract.
Identifiants
pubmed: 38129886
doi: 10.1186/s12964-023-01386-9
pii: 10.1186/s12964-023-01386-9
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
367Subventions
Organisme : Basic scientific research project of Liaoning Provincial Department of Education
ID : LJKMZ20221184
Organisme : the Science and Technology Plan of Liaoning Province
ID : 2021JH2/10300094
Organisme : Natural Science Foundation of Liaoning Province
ID : 2019-MS-372
Informations de copyright
© 2023. The Author(s).
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