Precision nephrotoxicity testing using 3D in vitro models.
3D culture model
Drug toxicity testing
Human primary renal cells
Nephrotoxicity
Precision medicine
Journal
Cell & bioscience
ISSN: 2045-3701
Titre abrégé: Cell Biosci
Pays: England
ID NLM: 101561195
Informations de publication
Date de publication:
21 Dec 2023
21 Dec 2023
Historique:
received:
04
04
2023
accepted:
15
12
2023
medline:
22
12
2023
pubmed:
22
12
2023
entrez:
22
12
2023
Statut:
epublish
Résumé
Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of which lack the complexity and functionality of the human kidney. 3D in vitro models are created by culturing human primary kidney cells derived from urine in a 3D microenvironment that mimics the fluid shear stresses of the kidney. Thus, 3D in vitro models provide more accurate and reliable predictions of human nephrotoxicity compared to existing 2D models. In this review, we focus on precision nephrotoxicity testing using 3D in vitro models with human autologous urine-derived kidney cells as a promising approach for evaluating drug safety.
Identifiants
pubmed: 38129901
doi: 10.1186/s13578-023-01187-0
pii: 10.1186/s13578-023-01187-0
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
231Subventions
Organisme : NIAID NIH HHS
ID : R21 AI152832
Pays : United States
Organisme : NIAID NIH HHS
ID : R03 AI165170
Pays : United States
Informations de copyright
© 2023. The Author(s).
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