Combined anti-Ro52/TRIM21 and anti-Ro60/SSA antibodies are associated with increased Sjögren's disease severity through interferon pathway activation.
Journal
Arthritis & rheumatology (Hoboken, N.J.)
ISSN: 2326-5205
Titre abrégé: Arthritis Rheumatol
Pays: United States
ID NLM: 101623795
Informations de publication
Date de publication:
21 Dec 2023
21 Dec 2023
Historique:
revised:
12
12
2023
received:
28
04
2023
accepted:
13
12
2023
medline:
22
12
2023
pubmed:
22
12
2023
entrez:
22
12
2023
Statut:
aheadofprint
Résumé
The biological diagnosis of primary Sjögren's disease (SjD) mainly relies on anti-Ro60/SSA antibodies, while the significance of anti-Ro52/TRIM21 antibodies currently remains unclear. The aim of this study was to characterize the clinical, serological, biological, transcriptomic and interferon profiles of SjD patients according to their anti-Ro52/TRIM21 antibody status. SjD patients from the European PRECISESADS (n=376) and the Brittany DIApSS (n=146) cohorts were divided into four groups: double negative (Ro52 In the DIAPSS cohort, Ro52 These results suggest that the combination of anti-Ro52/TRIM21 and anti-Ro60/SSA antibodies is associated with a clinical, biological, and transcriptional profile linked to greater disease severity in SjD, through the potentiation of the interferon pathway activation by anti-Ro52/TRIM21 antibodies.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Lorenzo Beretta
(L)
Barbara Vigone
(B)
Jacques-Olivier Pers
(JO)
Alain Saraux
(A)
Valérie Devauchelle-Pensec
(V)
Divi Cornec
(D)
Sandrine Jousse-Joulin
(S)
Bernard Lauwerys
(B)
Julie Ducreux
(J)
Anne-Lise Maudoux
(AL)
Carlos Vasconcelos
(C)
Ana Tavares
(A)
Esmeralda Neves
(E)
Raquel Faria
(R)
Mariana Brandão
(M)
Ana Campar
(A)
António Marinho
(A)
Fátima Farinha
(F)
Isabel Almeida
(I)
Miguel Ángel González-Gay
(MÁ)
Ricardo Blanco Alonso
(RB)
Alfonso Corrales Martínez
(AC)
Ricard Cervera
(R)
Ignasi Rodríguez-Pintó
(I)
Gerard Espinosa
(G)
Rik Lories
(R)
Ellen De Langhe
(E)
Nicolas Hunzelmann
(N)
Doreen Belz
(D)
Torsten Witte
(T)
Niklas Baerlecken
(N)
Georg Stummvoll
(G)
Michael Zauner
(M)
Michaela Lehner
(M)
Eduardo Collantes
(E)
Rafaela Ortega-Castro
(R)
Mª Angeles Aguirre-Zamorano
(MA)
Alejandro Escudero-Contreras
(A)
Mª Carmen Castro-Villegas
(MC)
Yolanda Jiménez Gómez
(YJ)
Norberto Ortego
(N)
María Concepción Fernández Roldán
(MCF)
Enrique Raya
(E)
Inmaculada Jiménez Moleón
(IJ)
Enrique de Ramon
(E)
Isabel Díaz Quintero
(ID)
Pier Luigi Meroni
(PL)
Maria Gerosa
(M)
Tommaso Schioppo
(T)
Carolina Artusi
(C)
Carlo Chizzolini
(C)
Aleksandra Dufour
(A)
Donatienne Wynar
(D)
Laszló Kovács
(L)
Attila Balog
(A)
Magdolna Deák
(M)
Márta Bocskai
(M)
Sonja Dulic
(S)
Gabriella Kádár
(G)
Falk Hiepe
(F)
Velia Gerl
(V)
Silvia Thiel
(S)
Manuel Rodriguez Maresca
(MR)
Antonio López-Berrio
(A)
Rocío Aguilar-Quesada
(R)
Héctor Navarro-Linares
(H)
Yiannis Ioannou
(Y)
Chris Chamberlain
(C)
Jacqueline Marovac
(J)
Marta Alarcón Riquelme
(MA)
Tania Gomes Anjos
(TG)
Lorenzo Beretta
(L)
Carlos Vasconcelos
(C)
Ricard Cervera
(R)
Ignasi Rodríguez-Pintó
(I)
Rik Lories
(R)
Ellen De Langhe
(E)
Torsten Witte
(T)
Eduardo Collantes
(E)
Rafaela Ortega-Castro
(R)
Yolanda Jiménez Gómez
(YJ)
Carlo Chizzolini
(C)
Laszló Kovács
(L)
Jacques-Olivier Pers
(JO)
Alain Saraux
(A)
Informations de copyright
This article is protected by copyright. All rights reserved.