Cognitive and emotional predictors of quality of life and functioning after COVID-19.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
21 Dec 2023
21 Dec 2023
Historique:
revised:
31
10
2023
received:
20
09
2023
accepted:
08
11
2023
medline:
22
12
2023
pubmed:
22
12
2023
entrez:
22
12
2023
Statut:
aheadofprint
Résumé
A long-term decline in health-related quality of life (HRQoL) has been reported after coronavirus disease 2019 (COVID-19). Studies with people with persistent symptoms showed inconsistent outcomes. Cognition and emotion are important determinants in HRQoL, but few studies have examined their prognostic significance for HRQoL and functionality in post-COVID patients with persisting symptoms. We aimed to describe QoL, HRQoL, and functioning in individuals post-COVID with varying COVID-19 severities and to investigate the predictive value of cognitive and emotional variables for QoL, HRQoL, and functioning. In total, 492 participants (398 post-COVID and 124 healthy controls) underwent a neurobehavioral examination that included assessments of cognition, mood, QoL/HRQoL (WHOQOL-BREF, EQ-5D), and functioning (WHODAS-II). Analysis of covariance and linear regression models were used to study intergroup differences and the relationship between cognitive and emotional variables and QoL and functioning. The Physical and Psychological dimensions of WHOQoL, EQ-5D, and WHODAS Cognition, Mobility, Life Activities, and Participation dimensions were significantly lower in post-COVID groups compared with a control group. Regression models explaining 23.9%-53.9% of variance were obtained for the WHOQoL-BREF dimensions and EQ-5D, with depressive symptoms, post-COVID symptoms, employment status, income, and mental speed processing as main predictors. For the WHODAS, models explaining 17%-60.2% of the variance were obtained. Fatigue, depressive symptoms, mental speed processing, and post-COVID symptoms were the main predictors. QoL/HRQoL and functioning after COVID-19 in individuals with persistent symptoms were lower than in non-affected persons. Depressive symptoms, fatigue, and slower mental processing speed were predictors of lower QoL/HRQoL and functioning.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agencia de Gestió d'Ajuts Universitaris i de Recerca
ID : Pandemies 2020PANDE00053
Organisme : Fundació la Marató de TV3
ID : 20211303132
Investigateurs
Jose A Bernia
(JA)
Vanesa Arauzo
(V)
Marta Balague-Marmaña
(M)
Silvia Cañizares
(S)
Jose Antonio Lopez Muñoz
(JAL)
Jesús Caballero
(J)
Anna Carnes-Vendrell
(A)
Gerard Piñol-Ripoll
(G)
Ester Gonzalez-Aguado
(E)
Carme Tayó-Juli
(C)
Eva Forcadell-Ferreres
(E)
Silvia Reverte-Vilarroya
(S)
Susanna Forné
(S)
Jordina Muñoz-Padros
(J)
Anna Bartes-Plan
(A)
Jose A Muñoz-Moreno
(JA)
Anna Prats-Paris
(A)
Anna Gasa-Roqué
(A)
Laura Casas Valls
(LC)
Marta Almeria
(M)
Judith Castejon
(J)
Maria José Ciudad
(MJ)
Anna Ferré
(A)
Manuela Lozano
(M)
Tamar Garzon
(T)
Marta Cullell
(M)
Sonia Vega
(S)
Sílvia Alsina
(S)
Maria J Maldonado-Belmonte
(MJ)
Susana Vazquez-Rivera
(S)
Eloy García-Cabello
(E)
Yaiza Molina
(Y)
Sandra Navarro
(S)
Eva Baillès
(E)
Informations de copyright
© 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
Références
Soriano JB, Murthy S, Marshall JC, Relan P, Diaz JV, WHO Clinical Case Definition Working Group on Post-COVID-19 Condition. A clinical case definition of post-COVID-19 condition by a Delphi consensus [Internet]. Lancet Infect Dis. 2022;22(4):e102-e107. http://www.thelancet.com/article/S1473309921007039/fulltext
Ballering AV, van Zon SKR, olde Hartman TC, Rosmalen JGM. Persistence of somatic symptoms after COVID-19 in The Netherlands: an observational cohort study [Internet]. Lancet. 2022;400(10350):452-461. doi:10.1016/S0140-6736(22)01214-4
ECDC. Prevalence of post COVID-19 condition symptoms: a systematic review and meta-analysis of cohort study data, stratified by recruitment setting [Internet]. Europe Centre for Disease Prevention and Control; 2022. https://www.ecdc.europa.eu/sites/default/files/documents/Prevalence-post-COVID-19-condition-symptoms.pdf
Davis HE, Assaf GS, McCorkell L, et al. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact [Internet]. EClinicalMedicine. 2021;38:101019. http://www.thelancet.com/article/S2589537021002996/fulltext
Ariza M, Cano N, Segura B, et al. Neuropsychological impairment in post-COVID condition individuals with and without cognitive complaints. Front Aging Neurosci. 2022;14:1-12.
Delgado-Alonso C, Valles-Salgado M, Delgado-Álvarez A, et al. Cognitive dysfunction associated with COVID-19: a comprehensive neuropsychological study. J Psychiatr Res. 2022;150(February):40-46.
García-Sánchez C, Calabria M, Grunden N, et al. Neuropsychological deficits in patients with cognitive complaints after COVID-19 [Internet]. Brain Behav. 2022;12:e2508. doi:10.1002/brb3.2508
Magnúsdóttir I, Lovik A, Unnarsdóttir AB, et al. Acute COVID-19 severity and mental health morbidity trajectories in patient populations of six nations: an observational study. Lancet Public Health. 2022;7(5):e406-e416.
Sampogna G, Di Vincenzo M, Giallonardo V, et al. The psychiatric consequences of long-COVID: a scoping review. J Pers Med. 2022;12(11):1767.
Badinlou F, Lundgren T, Jansson-Fröjmark M. Mental health outcomes following COVID-19 infection: impacts of post-COVID impairments and fatigue on depression, anxiety, and insomnia-a web survey in Sweden [Internet]. BMC Psychiatry. 2022;22(1):1-11. doi:10.1186/s12888-022-04405-0
Power M, Kuyken W. World Health Organization quality of life assessment (WHOQOL): development and general psychometric properties. Soc Sci Med. 1998;46(12):1569-1585.
Schipper H. Quality of life: principles of the clinical paradigm. J Psychosoc Oncol. 1990;8(2-3):71-185.
Sosnowski R, Kulpa M, Ziȩtalewicz U, et al. Basic issues concerning health-related quality of life [Internet]. Cent European J Urol. 2017;70(2):206. /pmc/articles/PMC5510334/.
Karimi M, Brazier J. Health, health-related quality of life, and quality of life: what is the difference? [Internet]. Pharmacoeconomics. 2016;34(7):645-649. doi:10.1007/s40273-016-0389-9
Kostanjsek N. Use of the international classification of functioning, disability and health (ICF) as a conceptual framework and common language for disability statistics and health information systems [Internet]. BMC Public Health. 2011;11(SUPPL. 4):1-6. doi:10.1186/1471-2458-11-S4-S3
Gil D, Tiscar C, Gómez M, et al. Health-related quality of life and stress-related disorders in COVID-19 ICU survivors: are they worse than with other causes of ARDS? [Internet]. J Intens Med. 2022;2(2):103. /pmc/articles/PMC8907013/.
Moens M, Duarte RV, De Smedt A, et al. Health-related quality of life in persons post-COVID-19 infection in comparison to normative controls and chronic pain patients. Front Public Health. 2022;10:3992.
O’Brien K, Townsend L, Dowds J, et al. 1-year quality of life and health-outcomes in patients hospitalised with COVID-19: a longitudinal cohort study. Respir Res. 2022;23:115. doi:10.1186/s12931-022-02032-7
D'ávila KG, Monaiar LR, Dantas LDP, et al. Decrease in health-related quality of life and post-COVID-19 syndrome in health care workers after SARS-CoV-2 infection: a cohort study. J Occup Environ Med. 2023;65(1):E1-E3.
Kim Y, Bae S, Chang HH, et al. Long COVID prevalence and impact on quality of life 2 years after acute COVID-19. Sci Rep. 2023;13:11207. doi:10.1038/s41598-023-36995-4
Larsson SB, von Feilitzen GS, Andersson ME, et al. Self-reported symptom severity, general health, and impairment in post-acute phases of COVID-19: retrospective cohort study of Swedish public employees [Internet]. Sci Rep. 2022;12(1):1-12. doi:10.1038/s41598-022-24307-1
Sacristán-Galisteo C, López-de-Uralde-Villanueva I, Del Corral T, Martín-Casas P. Functional status and quality of life in nonhospitalized COVID-19 survivors. Acad J Health Sci. 2022;37:58-64.
Tak CR. The health impact of long COVID: a cross-sectional examination of health-related quality of life, disability, and health status among individuals with self-reported post-acute sequelae of SARS CoV-2 infection at various points of recovery [Internet]. J Patient Rep Outcomes. 2023;7(1):31 /pmc/articles/PMC10029785/.
Walker S, Goodfellow H, Pookarnjanamorakot P, et al. Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study. BMJ Open. 2023;13(6):e069217.
Lemhöfer C, Sturm C, Loudovici-Krug D, Best N, Gutenbrunner C. The impact of post-COVID-Syndrome on functioning-results from a community survey in patients after mild and moderate SARS-CoV-2-infections in Germany. J Occup Med Toxicol. 2021;16(1):45. doi:10.1186/s12995-021-00337-9
Temperoni C, Grieco S, Pasquini Z, et al. Clinical characteristics, management and health related quality of life in young to middle age adults with COVID-19. MBC Infectious Diseases. 2021;21:1-10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848882/pdf/12879_2021_Article_5841.pdf
Iqbal A, Iqbal K, Arshad Ali S, et al. The COVID-19 Sequelae: a cross-sectional evaluation of post-recovery symptoms and the need for rehabilitation of COVID-19 survivors. Cureus. 2021;13(2):e13080. doi:10.7759/cureus.13080
Pappa S, Barmparessou Z, Athanasiou N, et al. Depression, insomnia and post-traumatic stress disorder in COVID-19 survivors: role of gender and impact on quality of life. J Pers Med. 2022;12(3):486. doi:10.3390/jpm12030486
Rass V, Beer R, Schiefecker AJ, et al. Neurological outcome and quality of life 3 months after COVID-19: a prospective observational cohort study [Internet]. Eur J Neurol. 2021;28(10):3348. /pmc/articles/PMC8250725/.
Albu S, Zozaya NR, Murillo N, García-Molina A, Chacón CAF, Kumru H. What's going on following acute COVID-19? Clinical characteristics of patients in an out-patient rehabilitation program. NeuroRehabilitation. 2021;48(4):469-480.
Verveen A, Wynberg E, van Willigen HDG, et al. Health-related quality of life among persons with initial mild, moderate, and severe or critical COVID-19 at 1 and 12 months after infection: a prospective cohort study. BMC Med. 2022;20(1):1-12.
Lehmann J, Holzner B, Giesinger JM, et al. Functional health and symptoms in Spain before and during the COVID-19 pandemic. BMC Public Health. 2021;21(1):1-10.
Malesevic S, Sievi NA, Baumgartner P, et al. Impaired health-related quality of life in long-COVID syndrome after mild to moderate COVID-19 [Internet]. Sci Rep. 2023;13(1):1-11. doi:10.1038/s41598-023-34678-8
Pirogovsky E, Woods SP, Vincent Filoteo J, Gilbert PE. Prospective memory deficits are associated with poorer everyday functioning in Parkinson's disease. J Int Neuropsychol Soc. 2012;18(6):986-995. doi:10.1017/S1355617712000781
Matsui M, Sumiyoshi T, Arai H, Higuchi Y, Kurachi M. Cognitive functioning related to quality of life in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(1):280-287.
Ratiu I, Virden TB, Baylow H, Flint M, Esfandiarei M. Executive function and quality of life in individuals with Marfan syndrome [Internet]. Qual Life Res. 2018;27(8):2057-2065. doi:10.1007/s11136-018-1859-7
Ho HT, Lin SI, Guo NW, Yang YC, Lin MH, Wang CS. Executive function predict the quality of life and negative emotion in older adults with diabetes: a longitudinal study [Internet]. Prim Care Diabetes. 2022;16(4):537-542. doi:10.1016/j.pcd.2022.05.002
Kiessling A, Henriksson P. Perceived cognitive function is a major determinant of health related quality of life in a non-selected population of patients with coronary artery disease-a principal components analysis. Qual Life Res. 2004;13(10):1621-1631.
Tozzi V, Costa M, Sampaolesi A, et al. Neurocognitive performance and quality of life in patients with HIV infection. AIDS Res Hum Retroviruses. 2003;19(8):643-652.
Palladini M, Bravi B, Colombo F, et al. Cognitive remediation therapy for post-acute persistent cognitive deficits in COVID-19 survivors: a proof-of-concept study. Neuropsychol Rehabil. 2023;33(7):1207-1224. doi:10.1080/09602011.2022.2075016
Poletti S, Palladini M, Mazza MG, et al. Long-term consequences of COVID-19 on cognitive functioning up to 6 months after discharge: role of depression and impact on quality of life. Eur Arch Psychiatry Clin Neurosci. 2022;272(5):773-782.
Cacciatore M, Raggi A, Pilotto A, et al. Neurological and mental health symptoms associated with post-COVID-19 disability in a sample of patients discharged from a COVID-19 ward: a secondary analysis. Int J Environ Res Public Health. 2022;19:4242. doi:10.3390/ijerph19074242
Fernández-de-las-Peñas C, Gómez-Mayordomo V, De-la-Llave-Rincón AI, et al. Anxiety, depression and poor sleep quality as long-term post-COVID sequelae in previously hospitalized patients: a multicenter study [Internet]. J Inf. 2021;83(4):496-522. http://www.journalofinfection.com/article/S0163445321003194/fulltext
Huang Y, Zhao N. Generalized anxiety disorder, depressive symptoms and sleep quality during COVID-19 outbreak in China: a web-based cross-sectional survey. Psychiatry Res. 2020;288:112954.
Huarcaya-Victoria J, Alarcon-Ruiz CA, Barzola-Farfán W, et al. One-year follow-up of depression, anxiety, and quality of life of Peruvian patients who survived COVID-19 [Internet]. Qual Life Res. 2023;32(1):139-149. doi:10.1007/s11136-022-03208-w
Mazza MG, Palladini M, De Lorenzo R, et al. One-year mental health outcomes in a cohort of COVID-19 survivors. J Psychiatr Res. 2022;145(August 2021):118-124.
Rass V, Ianosi BA, Zamarian L, et al. Factors associated with impaired quality of life three months after being diagnosed with COVID-19 [Internet]. Qual Life Res. 2022;31(5):1401-1414. doi:10.1007/s11136-021-02998-9
Mastrorosa I, Del Duca G, Pinnetti C, et al. What is the impact of post-COVID-19 syndrome on health-related quality of life and associated factors: a cross-sectional analysis [Internet]. Health Qual Life Outcomes. 2023;21(1):28. /pmc/articles/PMC10031164/.
Si TL, Chen P, Zhang L, et al. Depression and quality of life among Macau residents in the 2022 COVID-19 pandemic wave from the perspective of network analysis. Front Psychol. 2023;14(April):1-11.
Faul F, Erdfelder E, Lang A-G, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175-191.
Rusticus SA, Lovato CY. Impact of sample size and variability on the power and type I error rates of equivalence tests: a simulation study. Pract Assess Res Eval. 2014;19(11):1-10.
Jackson C. The chalder fatigue scale (CFQ 11) [Internet]. Occup Med. 2015;65(1):86. https://academic.oup.com/occmed/article/65/1/86/1433061
García-Campayo J, Zamorano E, Ruiz MA, et al. Cultural adaptation into Spanish of the generalized anxiety disorder-7 (GAD-7) scale as a screening tool [Internet]. Health Qual Life Outcomes. 2010;8:8. /pmc/articles/PMC2831043/.
Diez-Quevedo C, Rangil T, Sanchez-Planell L, Kroenke K, Spitzer RL. Validation and utility of the patient health questionnaire in diagnosing mental disorders in 1003 general hospital Spanish inpatients. Psychosom Med. 2001;63(4):679-686.
WHO. WHOQOL-BREF: Spanish version. World Health Organization. 2020;1-3.
Foundation ER. EQ-5D-3L User Guide [Internet]. 2018. https://euroqol.org/publications/user-guides
Organización Mundial de la Salud. Medición de la Salud y la Discapacidad [Internet]. 2015. https://apps.who.int/iris/bitstream/handle/10665/170500/9874573309_spa.pdf?sequence=1&isAllowed=y%0Ahttps://apps.who.int/iris/handle/10665/170500
Marshall JC, Murthy S, Diaz J, et al. A minimal common outcome measure set for COVID-19 clinical research. Lancet Infect Dis. 2020;20(8):e192-e197.
Sarda R, Kumar A, Chandra A, et al. Prevalence of long COVID-19 and its impact on quality of life among outpatients with mild COVID-19 disease at Tertiary Care Center in North India. J Patient Exp. 2022;9:23743735221117358. doi:10.1177/23743735221117358
Pires BMFB, Bosco PS, Nunes AS, et al. Post-COVID-19 health professionals' quality of LIFE: a cross-sectional study. Cogitare Enfermagem. 2021;26:e78275.
Rashid MU, Khan MAS, Dalal K, et al. Quality of life (QoL) among COVID-19 recovered healthcare workers in Bangladesh [Internet]. BMC Health Serv Res. 2022;22(1):1-13. doi:10.1186/s12913-022-07961-z
Castanares-Zapatero D, Chalon P, Kohn L, et al. Pathophysiology and mechanism of long COVID: a comprehensive review [Internet]. Ann Med. 2022;54(1):1473. /pmc/articles/PMC9132392/.
Doyle K, Weber E, Atkinson JH, et al. Aging, prospective memory, and health-related quality of life in HIV infection. AIDS Behav. 2012;16(8):2309-2318.
Sanchez-Luengos I, Lucas-Jiménez O, Ojeda N, et al. Predictors of health-related quality of life in Parkinson's disease: the impact of overlap between health-related quality of life and clinical measures [Internet]. Qual Life Res. 2022;31(11):3241-3252. doi:10.1007/s11136-022-03187-y
Ueoka Y, Tomotake M, Tanaka T, et al. Quality of life and cognitive dysfunction in people with schizophrenia [Internet]. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(1):53-59. doi:10.1016/j.pnpbp.2010.08.018
Townsend L, Dyer AH, Jones K, et al. Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection [Internet]. PLoS One. 2020;15(11):e0240784. doi:10.1371/journal.pone.0240784
Ollila H, Pihlaja R, Koskinen S, et al. Long-term cognitive functioning is impaired in ICU-treated COVID-19 patients: a comprehensive controlled neuropsychological study [Internet]. Crit Care. 2022;26(1):1-11. doi:10.1186/s13054-022-04092-z
Renaud-Charest O, Lui LMW, Eskander S, et al. Onset and frequency of depression in post-COVID-19 syndrome: a systematic review [Internet]. J Psychiatr Res. 2021;144(July):129-137. doi:10.1016/j.jpsychires.2021.09.054
Mazza MG, De Lorenzo R, Conte C, et al. Anxiety and depression in COVID-19 survivors: role of inflammatory and clinical predictors [Internet]. Brain Behav Immun. 2020;89:594-600. doi:10.1016/j.bbi.2020.07.037
Barker-Collo SL. Quality of life in multiple sclerosis: does information-processing speed have an independent effect? Arch Clin Neuropsychol. 2006;21(2):167-174.
Wadley VG, Bull TP, Zhang Y, et al. Cognitive processing speed is strongly related to driving skills, financial abilities, and other instrumental activities of daily living in persons with mild cognitive impairment and mild dementia. J Gerontol Ser A Biol Sci Med Sci. 2021;76(10):1829-1838.
Kilpinen R, Saunamäki T, Jehkonen M. Information processing speed in obstructive sleep apnea syndrome: a review. Acta Neurol Scand. 2014;129(4):209-218.
Khanahmadi M, Malmir M, Eskandari H, Orang T. Evaluation of visual information processing speed in depressed people. Iran J Public Health. 2013;42(11):1266-1273.
Ocon AJ. Caught in the thickness of brain fog: exploring the cognitive symptoms of chronic fatigue syndrome. Front Physiol. 2013;4:1-8.
Veldhuijzen DS, Sondaal SFV, Oosterman JM. Intact cognitive inhibition in patients with fibromyalgia but evidence of declined processing speed. J Pain. 2012;13(5):507-515.
Cassileth BR, Lusk EJ, Strouse TB, et al. Psychosocial status in chronic illness. N Engl J Med. 1984;311(8):506-511.
Chapman DP, Perry GS, Strine TW. The vital link between chronic disease and depressive disorders. Prev Chronic Dis. 2005;2(1):1-10.
Moussavi S, Chatterji S, Verdes E, et al. Depression, chronic diseases, and decrements in health: results from the world health surveys. Lancet. 2017;370(8):851-858.
Bottemanne H, Gouraud C, Hulot JS, et al. Do anxiety and depression predict persistent physical symptoms after a severe COVID-19 episode? A prospective study. Front Psychiatry. 2021;12(November):1-8.
Calabria M, García C, Nicholas S, et al. Post-COVID-19 fatigue: the contribution of cognitive and neuropsychiatric symptoms [Internet]. J Neurol. 2022;269:3990-3999. doi:10.1007/s00415-022-11141-8
Skinner JP, Moran LV. Persistent effects of COVID-19 in patients hospitalized during the first wave of the pandemic: the impact of persistent fatigue on quality of life in a cross-sectional study. J Med Virol. 2023;95(2):e28491.
Azcue N, Gómez-Esteban JC, Acera M, et al. Brain fog of post-COVID-19 condition and chronic fatigue syndrome, same medical disorder? [Internet]. J Transl Med. 2022;20(1):1-16. doi:10.1186/s12967-022-03764-2
Delgado-Alonso C, Díez-Cirarda M, Pagán J, et al. Unraveling brain fog in post-COVID syndrome: relationship between subjective cognitive complaints and cognitive function, fatigue, and neuropsychiatric symptoms. Eur J Neurol. 2023. doi:10.1111/ene.16084