Diterpenoid Alkaloids from Delphinium ajacis and Their Anti-inflammatory Activity.

Delphinium ajacis, diterpenoid alkaloids, anti-inflammatory activity

Journal

Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449

Informations de publication

Date de publication:
21 Dec 2023
Historique:
revised: 21 12 2023
received: 06 12 2023
accepted: 21 12 2023
medline: 22 12 2023
pubmed: 22 12 2023
entrez: 22 12 2023
Statut: aheadofprint

Résumé

Three novel diterpenoid alkaloids, comprising two C19-diterpenoid alkaloids (1 and 2) and one C20-diterpenoid alkaloid (3), were isolated from Delphinium ajacis, alongside the six known compounds (4-9). Their structures were elucidated by spectroscopic methods (MS, UV, IR, 1D and 2D NMR) and chemical properties. Simultaneously, the anti-inflammatory properties of all compounds (1-9) was conducted, focusing on nitric oxide (NO) production in LPS-induced BV-2 cells. The results indicated compounds 1-3, 7, and 8 have potential anti-inflammatory activity.

Identifiants

pubmed: 38130145
doi: 10.1002/cbdv.202301958
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202301958

Informations de copyright

© 2023 Wiley-VCH GmbH.

Auteurs

Qing Tang (Q)

Jinan University, College of Pharmacy, huangpudadao, 510632, Guangzhou, CHINA.

Xi Shen (X)

Jinan University, School of Medicine, huangpudadao, Guangzhou, CHINA.

Yi-Kun Hao (YK)

Jinan University, College of Pharmacy, huangpudadao, 510632, 052077, Guangzhou, CHINA.

Si-Yu Yang (SY)

Jinan University, School of Medicine, huangpudadao, 510632, Guangzhou, CHINA.

Jin-Tao Fu (JT)

Jinan University, College of Pharmacy, huangpudadao, Guangzhou, CHINA.

Tian-Yuan Wu (TY)

Jinan University, College of Pharmacy, huangpudadao, Guangzhou, CHINA.

Hai-Yue Zhao (HY)

Jinan University, College of Pharmacy, huangpudadao, Guangzhou, CHINA.

Bai-Fu Qin (BF)

Jinan University, School of Medicine, huangpudadao, Guangzhou, CHINA.

Yao-Lan Li (YL)

Jinan University, College of Pharmacy, huangpudadao, Guangzhou, CHINA.

Yu-Bo Zhang (YB)

Jinan University, School of Medicine, huangpudadao, Guangzhou, CHINA.

GuoCai Wang (G)

Jinan University, college of Pharmacy, 601, the west of Huangpu street, Not Available, 510632, Guangzhou, CHINA.

Classifications MeSH