NMR-based stability evaluation of (E)-1-(3',4'-dimethoxyphenyl)butadiene (DMPBD) from Zingiber cassumunar Roxb. rhizome.
DMPBD
NMR
Z. cassumunar
stability evaluation
Journal
Phytochemical analysis : PCA
ISSN: 1099-1565
Titre abrégé: Phytochem Anal
Pays: England
ID NLM: 9200492
Informations de publication
Date de publication:
22 Dec 2023
22 Dec 2023
Historique:
revised:
26
09
2023
received:
25
07
2023
accepted:
05
12
2023
medline:
22
12
2023
pubmed:
22
12
2023
entrez:
22
12
2023
Statut:
aheadofprint
Résumé
The active compound (E)-1-(3',4'-dimethoxyphenyl)butadiene (DMPBD) isolated from the rhizomes of Zingiber cassumunar Roxb. has potent anti-inflammatory and anticancer activities. Although DMPBD is one of the promising drug candidates for phytomedicine, its limited stability impedes its widespread use. For the development of new drugs, the assessment of their chemical stability is essential, ensuring they maintain their properties within specified limits throughout the period from production until use. In the present study, we aimed to evaluate the stability of DMPBD under various conditions, including different solvents, temperatures, and lighting conditions, to identify the factors affecting stability and optimize the storage and handling conditions. DMPBD samples subjected to the different conditions tested were monitored by quantitative Significant decomposition of DMPBD was observed in chloroform-d For pharmacological/therapeutic applications, DMPBD should be stored in the form of the crude extract or as a purified material in methanolic solution. Ideally, the storage temperature should be below 4°C and O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Thammasat University Research Fund
ID : TUFT 41/2564
Organisme : Thammasat University Research Unit in Cannabis and Herbal Products Innovation.
Organisme : The Thailand Science Research and Innovation Fundamental Fund fiscal year 2023
Informations de copyright
© 2023 John Wiley & Sons Ltd.
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