Abstinence Restores Cardiac Function in Mice with Established Alcohol-Induced Cardiomyopathy.
abstinence
alcohol-induced cardiomyopathy
cardiac function
reversal
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
07 Dec 2023
07 Dec 2023
Historique:
received:
11
10
2023
revised:
30
11
2023
accepted:
05
12
2023
medline:
22
12
2023
pubmed:
22
12
2023
entrez:
22
12
2023
Statut:
epublish
Résumé
Alcohol-induced cardiomyopathy (ACM) has a poor prognosis with up to a 50% chance of death within four years of diagnosis. There are limited studies investigating the potential of abstinence for promoting repair after alcohol-induced cardiac damage, particularly in a controlled preclinical study design. Here, we developed an exposure protocol that led to significant decreases in cardiac function in C57BL6/J mice within 30 days; dP/dt max decreased in the mice fed alcohol for 30 days (8054 ± 664.5 mmHg/s compared to control mice: 11,188 ± 724.2 mmHg/s,
Identifiants
pubmed: 38132102
pii: cells12242783
doi: 10.3390/cells12242783
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R21AA029747
Pays : United States
Organisme : NIH HHS
ID : F30AA030472
Pays : United States