[Genital lichen sclerosus and lichen planus].

Genitaler Lichen sclerosus und Lichen planus.

Cancer risk Inflammatory dermatoses of the genital area Quality of life Scarring Topical steroids

Journal

Dermatologie (Heidelberg, Germany)

ISSN: 2731-7013

Titre abrégé: Dermatologie (Heidelb)

Pays: Germany

ID NLM: 9918384885206676

Informations de publication

Date de publication:
22 Dec 2023

Historique:

accepted: 09 11 2023

medline: 22 12 2023

pubmed: 22 12 2023

entrez: 22 12 2023

Statut: aheadofprint

Résumé

Lichen sclerosus (LS) and lichen planus (LP) are chronic inflammatory dermatoses of unknown aetiology. They pose the most important differential diagnoses of inflammatory dermatoses in the genital area. There is often a delay in diagnosing LS and LP and subsequently treatment is initiated late in the course of the disease, which will lead to scarring and a decreased quality of life. There is an increased risk of the development of malignancies in the genital area in both diseases; however, early and continuous treatment with potent topical steroids will decrease this risk. Der Lichen sclerosus (LS) und Lichen planus (LP) sind chronische, entzündliche Hauterkrankungen unklarer Ätiologie. Sie sind die wichtigsten „gegenseitigen“ Differenzialdiagnosen entzündlicher Hauterkrankungen im Genitalbereich. Der LS und LP werden oft zu spät diagnostiziert und entsprechend zu spät behandelt, dies kann zu Vernarbungen mit schwerwiegenden Einschränkungen der Lebensqualität führen. Bei beiden Dermatosen besteht ein erhöhtes Risiko, Malignitäten im anogenitalen Bereich zu entwickeln, eine frühe und konsequente Behandlung mit potenten lokalen Kortisonexterna verringert dieses Risiko.

Autres résumés

Type: Publisher (ger)

Der Lichen sclerosus (LS) und Lichen planus (LP) sind chronische, entzündliche Hauterkrankungen unklarer Ätiologie. Sie sind die wichtigsten „gegenseitigen“ Differenzialdiagnosen entzündlicher Hauterkrankungen im Genitalbereich. Der LS und LP werden oft zu spät diagnostiziert und entsprechend zu spät behandelt, dies kann zu Vernarbungen mit schwerwiegenden Einschränkungen der Lebensqualität führen. Bei beiden Dermatosen besteht ein erhöhtes Risiko, Malignitäten im anogenitalen Bereich zu entwickeln, eine frühe und konsequente Behandlung mit potenten lokalen Kortisonexterna verringert dieses Risiko.

Identifiants

DOI: 10.1007/s00105-023-05267-7 PMID: 38133692

pubmed: 38133692

doi: 10.1007/s00105-023-05267-7

pii: 10.1007/s00105-023-05267-7

doi:

Types de publication

English Abstract Journal Article Review

Langues

ger

Sous-ensembles de citation

Informations de copyright

Références

Becker K (2011) Lichen sclerosus in boys. Dtsch Ärztebl Int 108:53–58

pubmed: 21307992 pmcid: 3036008

Becker K, Meissner V, Farwick W et al (2013) Lichen sclerosus and atopy in boys: coincidence or correlation? Br J Dermatol 168:362–366

doi: 10.1111/j.1365-2133.2012.11201.x pubmed: 22860989

Bermejo-Fenoll A, López-Jornet P (2006) Familial oral lichen planus: presentation of six families. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:e12–e15

doi: 10.1016/j.tripleo.2006.03.016 pubmed: 16876038

Bradford J, Fischer G (2013) Surgical division of labial adhesions in vulvar lichen sclerosus and lichen planus. J Low Genit Tract Dis 17:48–50

doi: 10.1097/LGT.0b013e31824f1427 pubmed: 22885642

Cheng S, Kirtschig G, Cooper S et al (2012) Interventions for erosive lichen planus affecting mucosal sites. Cochrane Database Syst Rev Cd008092:

Cooper SM, Ali I, Baldo M, Wojnarowska F (2008) The association of lichen sclerosus and erosive lichen planus of the vulva with autoimmune disease: a case-control study. Arch Dermatol 144:1432–1435

doi: 10.1001/archderm.144.11.1432 pubmed: 19015417

Cooper SM, Gao XH, Powell JJ, Wojnarowska F (2004) Does treatment of vulvar lichen sclerosus influence its prognosis? Arch Dermatol 140:702–706

doi: 10.1001/archderm.140.6.702 pubmed: 15210461

Edmonds EV, Hunt S, Hawkins D et al (2012) Clinical parameters in male genital lichen sclerosus: a case series of 329 patients. J Eur Acad Dermatol Venereol 26:730–737

doi: 10.1111/j.1468-3083.2011.04155.x pubmed: 21707769

Fazel N (2015) Cutaneous lichen planus: a systematic review of treatments. J Dermatolog Treat 26:280–283

doi: 10.3109/09546634.2014.933167 pubmed: 24916211

Feig JL, Gribetz ME, Lebwohl MG (2016) Chronic lichen sclerosus successfully treated with intralesional adalimumab. Br J Dermatol 174:687–689

doi: 10.1111/bjd.14212 pubmed: 26436412

Goldstein AT, Thaçi D, Luger T (2009) Topical calcineurin inhibitors for the treatment of vulvar dermatoses. Eur J Obstet Gynecol Reprod Biol 146:22–29

doi: 10.1016/j.ejogrb.2009.05.026 pubmed: 19631446

Gorouhi F, Davari P, Fazel N (2014) Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis. Sci World J 2014:742826

doi: 10.1155/2014/742826

Gulin SJ, Lundin F, Seifert O (2023) Comorbidity in patients with lichen sclerosus: a retrospective cohort study. Eur J Med Res 28:338

doi: 10.1186/s40001-023-01335-9 pubmed: 37697418 pmcid: 10494448

Halonen P, Jakobsson M, Heikinheimo O et al (2017) Lichen sclerosus and risk of cancer. Int J Cancer 140:1998–2002

doi: 10.1002/ijc.30621 pubmed: 28124469

Kirtschig G (2016) Lichen sclerosus-presentation, diagnosis and management. Dtsch Ärztebl Int 113:337–343

pubmed: 27232363 pmcid: 4904529

Kirtschig G, Cooper S (2016) Gynecologic dermatology: symptoms, signs and clinical management. JP Medical Ltd

Kirtschig G, Kinberger M, Kreuter A et al (2023) EuroGuiderm guideline lichen sclerosus. Version [1], June 2023. https://www.guidelines.edf.one/edf-guidelines-and-consensus-statements . Zugegriffen: Juni 2023

Kirtschig G, Kuik D (2014) A Dutch cohort study confirms familial occurrence of anogenital lichen sclerosus. J Women’s Health Care 3(6):1000209

Kirtschig G, Van Der Meulen AJ, Lipan IJW, Stoof TJ (2002) Successful treatment of erosive vulvovaginal lichen planus with topical tacrolimus. Br J Dermatol 147:625–626

doi: 10.1046/j.1365-2133.2002.488713.x pubmed: 12207624

Kirtschig G, Wakelin SH, Wojnarowska F (2005) Mucosal vulval lichen planus: outcome, clinical and laboratory features. J Eur Acad Dermatol Venereol 19:301–307

doi: 10.1111/j.1468-3083.2004.01167.x pubmed: 15857455

Kizer WS, Prarie T, Morey AF (2003) Balanitis xerotica obliterans: epidemiologic distribution in an equal access health care system. South Med J 96:9–11

doi: 10.1097/00007611-200301000-00004 pubmed: 12602705

Lee A, Bradford J, Fischer G (2015) Long-term management of adult vulvar lichen sclerosus: a prospective cohort study of 507 women. JAMA Dermatol 151:1061–1067

doi: 10.1001/jamadermatol.2015.0643 pubmed: 26070005

Lewis FM, Tatnall FM, Velangi SS et al (2018) British Association of Dermatologists guidelines for the management of lichen sclerosus, 2018. Br J Dermatol 178:839–853

doi: 10.1111/bjd.16241 pubmed: 29313888

Lowenstein EB, Zeichner JA (2013) Intralesional adalimumab for the treatment of refractory balanitis xerotica obliterans. JAMA Dermatol 149:23–24

doi: 10.1001/2013.jamadermatol.39 pubmed: 23324752

Marren P, Yell J, Charnock FM et al (1995) The association between lichen sclerosus and antigens of the HLA system. Br J Dermatol 132:197–203

doi: 10.1111/j.1365-2133.1995.tb05013.x pubmed: 7888355

Mirastschijski U, Schwenke C, Melchior S, Cedidi C (2017) Buried penis: a comprehensive review on aetiology, classification and plastic-surgical reconstruction. Handchir Mikrochir Plast Chir 49:78–84

pubmed: 28561167

Niamh L, Naveen S, Hazel B (2009) Diagnosis of vulval inflammatory dermatoses: a pathological study with clinical correlation. Int J Gynecol Pathol 28:554–558

doi: 10.1097/PGP.0b013e3181a9fb0d pubmed: 19851203

Pandey A, Dican R, Beier J, Keller H (2014) Buccal mucosal graft in reconstructive urology: uses beyond urethral stricture. Int J Urol 21:732–734

doi: 10.1111/iju.12403 pubmed: 25110793

Powell J, Wojnarowska F (2002) Childhood vulvar lichen sclerosus. The course after puberty. J Reprod Med 47:706–709

pubmed: 12380449

Powell J, Wojnarowska F, Winsey S et al (2000) Lichen sclerosus premenarche: autoimmunity and immunogenetics. Br J Dermatol 142:481–484

doi: 10.1046/j.1365-2133.2000.03360.x pubmed: 10735954

Rödder K, Olianas R, Fisch M (2006) Urethral strictures—operative strategy. Urologe 45:499–513

doi: 10.1007/s00120-006-1031-9

Sherman V, Mcpherson T, Baldo M et al (2010) The high rate of familial lichen sclerosus suggests a genetic contribution: an observational cohort study. J Eur Acad Dermatol Venereol 24:1031–1034

doi: 10.1111/j.1468-3083.2010.03572.x pubmed: 20202060

Simpson RC, Thomas KS, Leighton P, Murphy R (2013) Diagnostic criteria for erosive lichen planus affecting the vulva: an international electronic-Delphi consensus exercise. Br J Dermatol 169:337–343

doi: 10.1111/bjd.12334 pubmed: 23521206 pmcid: 3838629

Stein R, Beetz R, Thüroff JW (2011) Kinderurologie in Klinik und Praxis Bd. 3. vollständig überarbeitete und erweiterte Auflage. Thieme

Terlou A, Santegoets LA, Van Der Meijden WI et al (2012) An autoimmune phenotype in vulvar lichen sclerosus and lichen planus: a Th1 response and high levels of microRNA-155. J Invest Dermatol 132:658–666

doi: 10.1038/jid.2011.369 pubmed: 22113482

Tuyl LV, Zinger N, Heide IVD, Al E (2023) Scoping study on evidence to tackle high-burden under-researched medical conditions. Discussion paper

Van Der Meijden WI, Boffa MJ, Ter Harmsel B et al (2022) 2021 European guideline for the management of vulval conditions. J Eur Acad Dermatol Venereol 36:952–972

doi: 10.1111/jdv.18102

Wallace HJ (1971) Lichen sclerosus et atrophicus. Trans St Johns Hosp Dermatol Soc 57:9–30

pubmed: 5570266