Does leptin cause proximal gastric cancer in the obese? The role of serum leptin in the etiology of proximal gastric cancer.
proximal gastric cancer; obesity
serum leptin
Journal
Hormone molecular biology and clinical investigation
ISSN: 1868-1891
Titre abrégé: Horm Mol Biol Clin Investig
Pays: Germany
ID NLM: 101538885
Informations de publication
Date de publication:
25 Dec 2023
25 Dec 2023
Historique:
received:
12
11
2022
accepted:
03
10
2023
medline:
22
12
2023
pubmed:
22
12
2023
entrez:
22
12
2023
Statut:
aheadofprint
Résumé
The aim of the present study was to determine the correlation between obesity, serum levels of leptin and proximal gastric cancer. Sixty-four gastric cancer patients operated on with curative intent were included in the study. We determined the correlation between the preoperative serum levels of leptin and the tumor's location. Serum leptin levels were correlated significantly with the proximal third location (p=0.04), gastric outlet obstructing tumors (p<0.0001), CRP levels (p=0.03) and BMI (p<0.0001). Patients with high serum levels of leptin had significantly more intestinal types of gastric cancer (p=0.033) and better differentiation (p=0.009). The linear regression model determined the proximal tumor location (beta: 0.467; p=0.045), BMI (beta: 0.657; p=0.001), high preoperative serum albumin (beta: 0.563; p=0.016) and the presence of pyloric stenosis (beta: 0.525; p=0.006) as related significantly to serum leptin levels. The Cox proportional hazard model identified age (HR: 0.003; 95 % CI: 0-0.794; p=0.041), preoperative serum levels of leptin (HR: 0.125; 95 % CI: 0.018-0.887; p=0.037) and the number of extracted LNs (HR: 0.001; 95 % CI: 0-0.677; p=0.038) as independent prognostic factors. Serum levels of leptin were significantly elevated in patients with proximal gastric cancer, suggesting that the leptin's effect might be due to its systemic secretion. This might explain the higher incidence of proximal gastric cancer in obese patients. Elevated serum leptin levels were an independent prognostic factor.
Identifiants
pubmed: 38133933
pii: hmbci-2022-0101
doi: 10.1515/hmbci-2022-0101
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023 Walter de Gruyter GmbH, Berlin/Boston.
Références
Yang, P, Zhou, Y, Chen, B, Wan, HW, Jia, GQ, Bai, HL, et al.. Overweight, obesity and gastric cancer risk: results from a meta-analysis of cohort studies. Eur J Cancer 2009;45:2867–73. https://doi.org/10.1016/j.ejca.2009.04.019 .
doi: 10.1016/j.ejca.2009.04.019
Li, Q, Zhang, J, Zhou, Y, Qiao, L. Obesity and gastric cancer. Front Biosci 2012;17:2383–90, https://doi.org/10.2741/4059 .
doi: 10.2741/4059
Khan, MR, Farooqi, NB, Shahzad, N. Is proximal gastric cancer a different entity from distal gastric cancer? Anatomical site distribution of Signet ring cell carcinoma and its association with Helicobacter Pylori infection. J Ayub Med Coll Abbottabad 2020;32:194–7.
Alexandre, L, Long, E, Beales, ILP. Pathophysiological mechanisms linking obesity and esophageal adenocarcinoma. World J Gastrointest Pathophysiol 2014;5:534–49. https://doi.org/10.4291/wjgp.v5.i4.534 .
doi: 10.4291/wjgp.v5.i4.534
Elliott, JA, Reynolds, JV. Visceral obesity, metabolic syndrome, and esophageal adenocarcinoma. Front Oncol 2021;11:1–15. https://doi.org/10.3389/fonc.2021.627270 .
doi: 10.3389/fonc.2021.627270
Long, J, Beales, ILP. The role of obesity in oesophageal cancer development. Therap Adv Gastroenterol 2014;7:247–68. https://doi.org/10.1177/1756283X14538689 .
doi: 10.1177/1756283X14538689
Ishikawa, M, Kitayama, J, Nagawa, H. Expression pattern of leptin and leptin receptor (OB-R) in human gastric cancer. World J Gastroenterol 2006;12:5517–22, https://doi.org/10.3748/wjg.v12.i34.5517 .
doi: 10.3748/wjg.v12.i34.5517
Zhao, L, Shen, ZX, Luo, HS, Shen, L. Possible involvement of leptin and leptin receptor in developing gastric adenocarcinoma. World J Gastroenterol 2005;11:7666–70, https://doi.org/10.3748/wjg.v11.i48.7666 .
doi: 10.3748/wjg.v11.i48.7666
Siewert, JR, Stein, HJ. Classification of adenocarcinoma of the oesophagogastric junction. Br J Surg 1998;85:1457–9. https://doi.org/10.1046/j.1365-2168.1998.00940.x .
doi: 10.1046/j.1365-2168.1998.00940.x
Japanese Gastric Cancer Association . Japanese gastric cancer treatment guidelines 2014 (ver. 4). Gastric Cancer 2017;20:1–19. https://doi.org/10.1007/s10120-016-0622-4 .
doi: 10.1007/s10120-016-0622-4
Jagric, T. The impact of modifying the laparoscopic lymphadenectomy technique on the extent of lymphadenectomy in laparoscopically operated gastric cancer patients. A single-center study. Surgery Surg Endosc 2019;1:19–25.
Jagric, T. East meets West: the initial results of laparoscopic gastric cancer resections with Eastern principles in a single Western centre – a propensity score-matched study. Langenbeck’s Arch Surg 2021;406:2699–708. https://doi.org/10.1007/s00423-021-02283-w .
doi: 10.1007/s00423-021-02283-w
Bolukbas, FF, Kilic, H, Bolukbas, C, Gumus, M, Horoz, M, Nms, T, et al.. Serum leptin concentration and advanced gastrointestinal cancers a case controlled study. BMC Cancer 2004;4:1–4. https://doi.org/10.1186/1471-2407/4/29 .
doi: 10.1186/1471-2407/4/29
Tuzun, A, Uygun, A, Yesilova, Z, Ozel, AM, Erdil, A, Yaman, H, et al.. Leptin levels in the acute stage of ulcerative colitis. J Gastroenterol Hepatol 2004;19:429–32, https://doi.org/10.1111/j.1440-1746.2003.03300.x .
doi: 10.1111/j.1440-1746.2003.03300.x
Tas, F, Karabulut, S, Ertuk, K, Duranyildiz, D. Clinical significance of serum leptin level in patients with gastric cancer. Eur Cytokine Netw 2018;29:52–8. https://doi.org/10.1684/ecn.2018.0408 .
doi: 10.1684/ecn.2018.0408
Isyraqiah, F, Kutty, MK, Durairajanayagam, D, Salim, N, Sigh, H. Leptin induces the expression of tumorogenic genes in the gastric mucosa of male Sprague-Dawley rats. Exp Biol Med 2018;243:1118–24. https://doi.org/10.1177/1535370218813909 .
doi: 10.1177/1535370218813909
Pai, R, Lin, C, Tran, T, Tarnawski, A. Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation. Biochem Biophys Res Commun 2005;331:984–92. https://doi.org/10.10116/j.bbre.2005.03.236 .
doi: 10.10116/j.bbre.2005.03.236
Gang, Y, Wang, J, Wang, R, Wang, K, Xu, Y, Song, G, et al.. Leptin and HER-2 are associated with gastric cancer progression and prognosis of patients. Biomed Pharmacother 2012;66:419–24. https://doi.org/10.1016/j.biopha.2012.03.002 .
doi: 10.1016/j.biopha.2012.03.002
Bharadwaj, S, Ginoya, S, Gohel, TD, Guirguis, J, Vallabh, H, Jevenn, A, et al.. Malnutrition: laboratory markers vs nutritional assessment. Gastroenterol Rep 2016;4:272–80. https://doi.org/10.1093/gastro/gow013 .
doi: 10.1093/gastro/gow013
Cheong, M, Chew, STH, Oliver, J, Baggs, G, Low, YL, How, CH, et al.. Nutritional biomarkers and associated factors in community-dwelling older adults: findings from the SHIELD study. Nutrients 2020;12:3–22. https://doi.org/10.3390/nu12113329 .
doi: 10.3390/nu12113329