A vibrating ingestible bioelectronic stimulator modulates gastric stretch receptors for illusory satiety.

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
22 Dec 2023
Historique:
medline: 22 12 2023
pubmed: 22 12 2023
entrez: 22 12 2023
Statut: ppublish

Résumé

Effective therapies for obesity require invasive surgical and endoscopic interventions or high patient adherence, making it challenging for patients with obesity to effectively manage their disease. Gastric mechanoreceptors sense distension of the stomach and perform volume-dependent vagal signaling to initiate the gastric phase and influence satiety. In this study, we developed a new luminal stimulation modality to specifically activate these gastric stretch receptors to elicit a vagal afferent response commensurate with mechanical distension. We designed the Vibrating Ingestible BioElectronic Stimulator (VIBES) pill, an ingestible device that performs luminal vibratory stimulation to activate mechanoreceptors and stroke mucosal receptors, which induces serotonin release and yields a hormonal metabolic response commensurate with a fed state. We evaluated VIBES across 108 meals in swine which consistently led to diminished food intake (~40%,

Identifiants

DOI: 10.1126/sciadv.adj3003 PMID: 38134286
pubmed: 38134286
doi: 10.1126/sciadv.adj3003
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadj3003

Auteurs

Shriya S Srinivasan (SS)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Society of Fellows, Harvard University, Cambridge, MA 02138, USA.
ORCID: 0000-0002-2508-1324

Amro Alshareef (A)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0001-8813-2531

Alexandria Hwang (A)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-9280-8394

Ceara Byrne (C)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Johannes Kuosmanen (J)

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Keiko Ishida (K)

Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0003-0894-296X

Joshua Jenkins (J)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0001-7698-9888

Sabrina Liu (S)

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0002-3471-3397

Wiam Abdalla Mohammed Madani (WAM)

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Alison M Hayward (AM)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0002-9581-8563

Niora Fabian (N)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0001-5871-0206

Giovanni Traverso (G)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0001-7851-4077

Classifications MeSH