Early and exclusive enteral nutrition in infants born very preterm.

To characterise the effects of early and exclusive enteral nutrition with either maternal or donor milk in infants born very preterm (28 Parallel-group, unmasked randomised controlled trial. Regional, tertiary neonatal intensive care unit. 102 infants born very preterm between 2021 and 2022 (51 in each group). Infants randomised to the intervention group received 60-80 mL/kg/day within the first 36 hours after birth. Infants randomised to the control group received 20-30 mL/kg/day (standard trophic feeding volumes). The primary outcome was the number of full enteral feeding days (>150 mL/kg/day) in the first 28 days after birth. Secondary outcomes included growth and body composition at the end of the first two postnatal weeks, and length of hospitalisation. The mean birth weight was 1477 g (SD: 334). Half of the infants were male, and 44% were black. Early and exclusive enteral nutrition increased the number of full enteral feeding days (+2; 0-2 days; p=0.004), the fat-free mass-for-age z-scores at postnatal day 14 (+0.5; 0.1-1.0; p=0.02) and the length-for-age z-scores at the time of hospital discharge (+0.6; 0.2-1.0; p=0.002). Hospitalisation costs differed between groups (mean difference favouring the intervention group: -$28 754; -$647 to -$56 861; p=0.04). In infants born very preterm, early and exclusive enteral nutrition increases the number of full enteral feeding days. This feeding practice may also improve fat-free mass accretion, increase length and reduce hospitalisation costs. NCT04337710.

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Déclaration de conflit d'intérêts

Competing interests: AAS has a patent for an instrumented feeding bottle. Additionally, AAS has provided scientific advice to Resbiotic, received consulting fees for participating in advisory board meetings for Reckitt/Mead Johnson Nutrition and received speaking fees for participating in educational activities organised by p-value communications and WebMD.