Application of novel PACS-based informatics platform to identify imaging based predictors of CDKN2A allelic status in glioblastomas.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
22 Dec 2023
Historique:
received: 08 03 2023
accepted: 01 12 2023
medline: 23 12 2023
pubmed: 23 12 2023
entrez: 22 12 2023
Statut: epublish

Résumé

Gliomas with CDKN2A mutations are known to have worse prognosis but imaging features of these gliomas are unknown. Our goal is to identify CDKN2A specific qualitative imaging biomarkers in glioblastomas using a new informatics workflow that enables rapid analysis of qualitative imaging features with Visually AcceSAble Rembrandtr Images (VASARI) for large datasets in PACS. Sixty nine patients undergoing GBM resection with CDKN2A status determined by whole-exome sequencing were included. GBMs on magnetic resonance images were automatically 3D segmented using deep learning algorithms incorporated within PACS. VASARI features were assessed using FHIR forms integrated within PACS. GBMs without CDKN2A alterations were significantly larger (64 vs. 30%, p = 0.007) compared to tumors with homozygous deletion (HOMDEL) and heterozygous loss (HETLOSS). Lesions larger than 8 cm were four times more likely to have no CDKN2A alteration (OR: 4.3; 95% CI 1.5-12.1; p < 0.001). We developed a novel integrated PACS informatics platform for the assessment of GBM molecular subtypes and show that tumors with HOMDEL are more likely to have radiographic evidence of pial invasion and less likely to have deep white matter invasion or subependymal invasion. These imaging features may allow noninvasive identification of CDKN2A allele status.

Identifiants

pubmed: 38135704
doi: 10.1038/s41598-023-48918-4
pii: 10.1038/s41598-023-48918-4
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

22942

Informations de copyright

© 2023. The Author(s).

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Auteurs

Niklas Tillmanns (N)

Brain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, 333 Cedar Street, PO Box 208042, New Haven, CT, 06520, USA.
Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany.

Jan Lost (J)

Brain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, 333 Cedar Street, PO Box 208042, New Haven, CT, 06520, USA.

Joanna Tabor (J)

Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.

Sagar Vasandani (S)

Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.

Shaurey Vetsa (S)

Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.

Neelan Marianayagam (N)

Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.

Kanat Yalcin (K)

Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.

E Zeynep Erson-Omay (EZ)

Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.

Marc von Reppert (M)

Brain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, 333 Cedar Street, PO Box 208042, New Haven, CT, 06520, USA.

Leon Jekel (L)

Brain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, 333 Cedar Street, PO Box 208042, New Haven, CT, 06520, USA.

Sara Merkaj (S)

Brain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, 333 Cedar Street, PO Box 208042, New Haven, CT, 06520, USA.

Divya Ramakrishnan (D)

Brain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, 333 Cedar Street, PO Box 208042, New Haven, CT, 06520, USA.

Arman Avesta (A)

Department of Radiation Oncology, Yale School of Medicine, 333 Cedar Street, PO Box 208042, New Haven, CT, 06520, USA.

Irene Dixe de Oliveira Santo (ID)

Brain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, 333 Cedar Street, PO Box 208042, New Haven, CT, 06520, USA.

Lan Jin (L)

R&D, Sema4, 333 Ludlow Street, North Tower, 8th Floor, Stamford, CT, 06902, USA.

Anita Huttner (A)

Department of Pathology, Yale School of Medicine, New Haven, CT, USA.

Khaled Bousabarah (K)

Visage Imaging, GmbH., Lepsiusstraße 70, 12163, Berlin, Germany.

Ichiro Ikuta (I)

Department of Radiology, Mayo Clinic Arizona, 5711 E Mayo Blvd, Phoenix, AZ, 85054, USA.

MingDe Lin (M)

Brain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, 333 Cedar Street, PO Box 208042, New Haven, CT, 06520, USA.
Visage Imaging, Inc., 12625 High Bluff Dr, Suite 205, San Diego, CA, 92130, USA.

Sanjay Aneja (S)

Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.

Bernd Turowski (B)

Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany.

Mariam Aboian (M)

Brain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, 333 Cedar Street, PO Box 208042, New Haven, CT, 06520, USA. mariam.aboian@yale.edu.
, New Haven, USA. mariam.aboian@yale.edu.

Jennifer Moliterno (J)

Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.

Classifications MeSH