In-vitro antimalarial activity of methanolic leaf- and stem-derived extracts from four Annonaceae plants.
Annonaceae
Artabotrys burmanicus
Malaria
Marsypopetalum modestum
Plasmodium falciparum
Journal
BMC research notes
ISSN: 1756-0500
Titre abrégé: BMC Res Notes
Pays: England
ID NLM: 101462768
Informations de publication
Date de publication:
22 Dec 2023
22 Dec 2023
Historique:
received:
07
03
2023
accepted:
11
12
2023
medline:
23
12
2023
pubmed:
23
12
2023
entrez:
22
12
2023
Statut:
epublish
Résumé
Plants in the Annonaceae family are known for having abundant biologically active secondary metabolites. They have been used in alternative drugs for various diseases in several countries, for instance, the bark of Cananga odorata (Lam.) Hook and Thomson is used for Ophthalmic inflammation and wound healing in Malaysia. Extracts from the leaves and stems of four Annonaceae plants, namely Uvaria longipes (Craib) L.L.Zhou, Y.C.F.Su & R.M.K.Saunders, Dasymaschalon sp., Artabotrys burmanicus A.DC, and Marsypopetalum modestum (Pierre) B.Xue & R.M.K.Saunders were investigated for growth inhibitory activity against blood-stage Plasmodium falciparum growth in vitro and for non-specific cytotoxicity against normal peripheral blood mononuclear cells (PBMCs). Antimalarial activity was assessed by invasion inhibition assay and the percentage of infected red blood cells on blood smears were determined. Cytotoxicity was tested by culturing PBMCs with the extracts, and viabilities were determined by Annexin V/propidium iodide staining. A. burmanicus stem extract and M. modestum leaf extract were capable of inhibiting growth of P. falciparum when used at 200 µg/mL compared to chloroquine. The extracts at effective concentrations, did not affect the viability of PBMCs. These results support further need for characterization of active compounds from specific Annonaceae plants in order to exploit their components for potential malaria treatment.
Identifiants
pubmed: 38135870
doi: 10.1186/s13104-023-06664-w
pii: 10.1186/s13104-023-06664-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
381Subventions
Organisme : Chiang Mai University
ID : N/A
Organisme : Chiang Mai University
ID : N/A
Organisme : Chiang Mai University
ID : N/A
Organisme : Chiang Mai University
ID : N/A
Organisme : The Higher Education Commission/Thailand Research Fund
ID : MRG5680080 (PL)
Informations de copyright
© 2023. The Author(s).
Références
Christenhusz MJM, Byng JW. The number of known plants species in the world and its annual increase. Phytotaxa. 2016;261(3):201–17.
doi: 10.11646/phytotaxa.261.3.1
Couvreur TLP, Pirie MD, Chatrou LW, Saunders RMK, Su YCF, Richardson JE, Erkens RHJ. Early evolutionary history of the flowering plant family Annonaceae: steady diversification and boreotropical geodispersal. J Biogeogr. 2011;38(4):664–80.
doi: 10.1111/j.1365-2699.2010.02434.x
Aminimoghadamfarouj N, Nematollahi A, Wiart C. Annonaceae: bio-resource for tomorrow’s drug discovery. J Asian Nat Prod Res. 2011;13(5):465–76.
doi: 10.1080/10286020.2011.570265
pubmed: 21534046
Moreira IC, Lago JHG, Roque NF. Alkaloid, flavonoids and terpenoids from leaves and fruits of Xylopia emarginata (Annonaceae). Biochem Syst Ecol. 2003;31(5):535–7.
doi: 10.1016/S0305-1978(02)00180-1
Schlitzer M. Antimalarial Drugs - what is in use and what is in the pipeline. Arch Pharm. 2008;341(3):149–63.
doi: 10.1002/ardp.200700184
Achan J, Talisuna AO, Erhart A, Yeka A, Tibenderana JK, Baliraine FN, Rosenthal PJ, D’Alessandro U. Quinine, an old anti-malarial drug in a modern world: role in the treatment of Malaria. Malar J. 2011. 10.
Petersen I, Eastman R, Lanzer M. Drug-resistant malaria: molecular mechanisms and implications for public health. FEBS Lett. 2011;585(11):1551–62.
doi: 10.1016/j.febslet.2011.04.042
pubmed: 21530510
Noreen N, Ullah A, Salman SM, Mabkhot Y, Alsayari A, Badshah SL. New insights into the spread of resistance to artemisinin and its analogues. J Glob Antimicrob Resist. 2021;27:142–9.
doi: 10.1016/j.jgar.2021.09.001
pubmed: 34517141
Frausin G, Lima RBS, Hidalgo AF, Maas P, Pohlit AM. Plants of the Annonaceae traditionally used as antimalarials: a review. Revista Brasileira De Fruticultura. 2014;36:315–37.
doi: 10.1590/S0100-29452014000500038
Elkington BG, Sydara K, Newsome A, Hwang CH, Lankin DC, Simmler C, Napolitano JG, Ree R, Graham JG, Gyllenhaal C, et al. New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos. J Ethnopharmacol. 2014;151(2):903–11.
doi: 10.1016/j.jep.2013.11.057
pubmed: 24333958
Chuakul WP, Jenjittikul S. T Thai Herbal Medicine Encyclopedia. Volume 4. Mahidol University Foundation; 2000.
Pumiputavon K, Chaowasku T, Saenjum C, Osathanunkul M, Wungsintaweekul B, Chawansuntati K, Wipasa J, Lithanatudom P. Cell cycle arrest and apoptosis induction by methanolic leaves extracts of four Annonaceae plants. BMC Complement Altern Med. 2017;17(1):294.
doi: 10.1186/s12906-017-1811-3
pubmed: 28583139
pmcid: 5460496
Pumiputavon K, Chaowasku T, Saenjum C, Osathanunkul M, Wungsintaweekul B, Chawansuntati K, Lithanatudom P, Wipasa J. Cytotoxic and cytostatic effects of four Annonaceae plants on human cancer cell lines. vitro Cell Dev Biology Anim. 2019;55(9):723–32.
doi: 10.1007/s11626-019-00393-w
Phromnoi K, Suttajit M, Saenjum C, Limtrakul Dejkriengkraikul P. Inhibitory effect of a Rosmarinic acid-enriched fraction prepared from Nga-Mon (Perilla frutescens) seed meal on Osteoclastogenesis through the RANK Signaling Pathway. Antioxid (Basel) 2021, 10(2).
Yang H, Zhang N, Zeng Q, Yu Q, Ke S, Li X. HPLC Method for the simultaneous determination of ten Annonaceous Acetogenins after Supercritical Fluid CO2 extraction. Int J Biomed Sci. 2010;6(3):202–7.
doi: 10.59566/IJBS.2010.6202
pubmed: 23675194
pmcid: 3615266
Trager W, Jensen JB. Human Malaria parasites in continuous culture. Science. 1976;193(4254):673–5.
doi: 10.1126/science.781840
pubmed: 781840
Organization WH. Malaria eradication: benefits, future scenarios and feasibility. Geneva; 2020.
Global Malaria Programme. [ https://www.who.int/teams/global-malaria-programme/elimination/q-a-on-malaria-eradication ].
Odoh UE, Uzor PF, Eze CL, Akunne TC, Onyegbulam CM, Osadebe PO. Medicinal plants used by the people of Nsukka Local Government Area, south-eastern Nigeria for the treatment of Malaria: an ethnobotanical survey. J Ethnopharmacol. 2018;218:1–15.
doi: 10.1016/j.jep.2018.02.034
pubmed: 29477369
Olorunnisola OS, Adetutu A, Balogun EA, Afolayan AJ. Ethnobotanical survey of medicinal plants used in the treatment of Malaria in Ogbomoso, Southwest Nigeria. J Ethnopharmacol. 2013;150(1):71–8.
doi: 10.1016/j.jep.2013.07.038
pubmed: 23920250
Tsabang N, Fokou PV, Tchokouaha LR, Noguem B, Bakarnga-Via I, Nguepi MS, Nkongmeneck BA, Boyom FF. Ethnopharmacological survey of Annonaceae medicinal plants used to treat Malaria in four areas of Cameroon. J Ethnopharmacol. 2012;139(1):171–80.
doi: 10.1016/j.jep.2011.10.035
pubmed: 22079831
Bhatt D, Kumar S, Kumar P, Bisht S, Kumar A, Maurya AK, Pal A, Bawankule DU. Rutin ameliorates Malaria pathogenesis by modulating inflammatory mechanism: an in vitro and in vivo study. Inflammopharmacology. 2022;30(1):159–71.
doi: 10.1007/s10787-021-00920-w
pubmed: 35064431
Olanlokun JO, Balogun AA, Olorunsogo OO, INFLUENCE OF ARTESUNATE COMBINATIVE THERAPY CO-ADMINISTRATION WITH RUTIN ON INFLAMMATORY CYTOKINES AND IMMUNOGLOBULINS IN PLASMODIUM BERGHEI-INFECTED MICE. J Parasitol. 2021;107(4):639–47.
doi: 10.1645/20-87
pubmed: 34358312
Hanif H, Abdollahi V, Javani Jouni F, Nikoukar M, Rahimi Esboei B, Shams E, Vazini H. Quercetin nano phytosome: as a novel anti-leishmania and anti-malarial natural product. J Parasit Dis. 2023;47(2):257–64.
doi: 10.1007/s12639-022-01561-8
pubmed: 36685738
pmcid: 9838256
Fulgheri F, Aroffu M, Ramírez M, Román-Álamo L, Peris JE, Usach I, Nacher A, Manconi M, Fernàndez-Busquets X, Manca ML. Curcumin or quercetin loaded nutriosomes as oral adjuvants for Malaria Infections. Int J Pharm. 2023;643:123195.
doi: 10.1016/j.ijpharm.2023.123195
pubmed: 37394159
Adeoye AO, Olanlokun JO, Tijani H, Lawal SO, Babarinde CO, Akinwole MT, Bewaji CO. Molecular docking analysis of apigenin and quercetin from ethylacetate fraction of Adansonia digitata with malaria-associated calcium transport protein: an in silico approach. Heliyon. 2019;5(9):e02248.
doi: 10.1016/j.heliyon.2019.e02248
pubmed: 31687530
pmcid: 6819832
Chiu HF, Chih TT, Hsian YM, Tseng CH, Wu MJ, Wu YC. Bullatacin, a potent antitumor Annonaceous acetogenin, induces apoptosis through a reduction of intracellular cAMP and cGMP levels in human hepatoma 2.2.15 cells. Biochem Pharmacol. 2003;65(3):319–27.
doi: 10.1016/S0006-2952(02)01554-X
pubmed: 12527325
Zhao GX, Miesbauer LR, Smith DL, McLaughlin JL. Asimin, asiminacin, and asiminecin: novel highly cytotoxic asimicin isomers from Asimina triloba. J Med Chem. 1994;37(13):1971–6.
doi: 10.1021/jm00039a009
pubmed: 8027979
Adepiti AO, Iwalewa EO. Evaluation of the combination of Uvaria chamae (P. Beauv.) And amodiaquine in murine Malaria. J Ethnopharmacol. 2016;193:30–5.
doi: 10.1016/j.jep.2016.07.035
pubmed: 27416806
Gathirwa JW, Rukunga GM, Mwitari PG, Mwikwabe NM, Kimani CW, Muthaura CN, Kiboi DM, Nyangacha RM, Omar SA. Traditional herbal antimalarial therapy in Kilifi district, Kenya. J Ethnopharmacol. 2011;134(2):434–42.
doi: 10.1016/j.jep.2010.12.043
pubmed: 21211554
Ranasinghe S, Ansumana R, Lamin JM, Bockarie AS, Bangura U, Buanie JA, Stenger DA, Jacobsen KH. Herbs and herbal combinations used to treat suspected Malaria in Bo, Sierra Leone. J Ethnopharmacol. 2015;166:200–4.
doi: 10.1016/j.jep.2015.03.028
pubmed: 25794802
Chokchaisiri R, Chaichompoo W, Chalermglin R, Suksamrarn A. Potent antiplasmodial alkaloids and flavonoids from Dasymaschalon Acuminatum. Records of Natural Products. 2015;9(2):243–6.