Niemann-Pick Disease Type C (NPDC) by Mutation of
Niemann-Pick disease type C
cholesterol trafficking
lysosomal proteins
lysosomal storage disorders
oxidative stress
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
21 Nov 2023
21 Nov 2023
Historique:
received:
24
10
2023
revised:
13
11
2023
accepted:
17
11
2023
medline:
23
12
2023
pubmed:
23
12
2023
entrez:
23
12
2023
Statut:
epublish
Résumé
Cholesterol trafficking is initiated by the endocytic pathway and transported from endo/lysosomes to other intracellular organelles. Deficiencies in cholesterol-sensing and binding proteins NPC1 and NPC2 induce accumulation in lysosomes and the malfunction of trafficking to other organelles. Each organelle possesses regulatory factors to induce cholesterol trafficking. The mutation of
Identifiants
pubmed: 38136141
pii: antiox12122021
doi: 10.3390/antiox12122021
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Research Foundation of Korea (NRF) grant funded by the Korean government
ID : 2022R1A2C1003890 (JHH)