Brain Pathways in LIS1-Associated Lissencephaly Revealed by Diffusion MRI Tractography.
DTI
LIS1
MRI
lissencephaly
tractography
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
29 Nov 2023
29 Nov 2023
Historique:
received:
01
11
2023
revised:
22
11
2023
accepted:
25
11
2023
medline:
23
12
2023
pubmed:
23
12
2023
entrez:
23
12
2023
Statut:
epublish
Résumé
Lissencephaly (LIS) is a rare neurodevelopmental disorder with severe symptoms caused by abnormal neuronal migration during cortical development. It is caused by both genetic and non-genetic factors. Despite frequent studies about the cortex, comprehensive elucidation of structural abnormalities and their effects on the white matter is limited. The main objective of this study is to analyze abnormal neuronal migration pathways and white matter fiber organization in LIS1-associated LIS using diffusion MRI (dMRI) tractography. For this purpose, slabs of brain specimens with LIS (
Identifiants
pubmed: 38137102
pii: brainsci13121655
doi: 10.3390/brainsci13121655
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NINDS NIH HHS
ID : R01 NS109475
Pays : United States