Chlorine in an Organic Molecule, a Universal Promoter-Workhorse-Of Reactions.
Darzens reaction
base induced β-elimination
chlorine as electrophilic center
dichlorocarbene
nucleophilic substitution of chlorine
phase transfer catalysis
vicarious nucleophilic substitution
α-halocarbanions
γ-halocarbanions
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
05 Dec 2023
05 Dec 2023
Historique:
received:
25
10
2023
revised:
26
11
2023
accepted:
01
12
2023
medline:
23
12
2023
pubmed:
23
12
2023
entrez:
23
12
2023
Statut:
epublish
Résumé
Due to the electronic configuration of the atom and charge of the nucleus, the chlorine in organic molecules can exert a variety of effects. It can depart as a chloride anion in the process of substitution and elimination, facilitates the abstraction of protons and stabilizes generated carbanions, exerts moderate stabilizing effect of carbenes, carbocations and radicals. There are frequent cases where chlorine substituent promotes more than one transformation. These rich effects of chlorine substituent will be illustrated by examples of our work.
Identifiants
pubmed: 38138446
pii: molecules28247957
doi: 10.3390/molecules28247957
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM