Bench to Bedside Development of [

[18F]Fluoromethyl-(1,2-2H4)choline cell membrane metabolism choline dosimetry in vitro in vivo metastatic castrate-resistant prostate cancer positron emission tomography

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
08 Dec 2023
Historique:
received: 15 11 2023
revised: 05 12 2023
accepted: 06 12 2023
medline: 23 12 2023
pubmed: 23 12 2023
entrez: 23 12 2023
Statut: epublish

Résumé

Malignant transformation is characterised by aberrant phospholipid metabolism of cancers, associated with the upregulation of choline kinase alpha (CHKα). Due to the metabolic instability of choline radiotracers and the increasing use of late-imaging protocols, we developed a more stable choline radiotracer, [

Identifiants

DOI: 10.3390/molecules28248018 PMID: 38138508
pubmed: 38138508
pii: molecules28248018
doi: 10.3390/molecules28248018
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : CRUK
ID : NCITA; C2536/A28680

Auteurs

Amarnath Challapalli (A)

Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
Department of Clinical Oncology, Bristol Haematology and Oncology Center, Horfield Road, Bristol BS2 8ED, UK.
ORCID: 0000-0002-3683-9583

Tara D Barwick (TD)

Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
Department of Radiology & Nuclear Medicine, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK.

Suraiya R Dubash (SR)

Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

Marianna Inglese (M)

Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

Matthew Grech-Sollars (M)

Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
ORCID: 0000-0003-3881-4870

Kasia Kozlowski (K)

Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

Henry Tam (H)

Department of Radiology & Nuclear Medicine, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK.

Neva H Patel (NH)

Department of Radiology & Nuclear Medicine, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK.

Mathias Winkler (M)

Department of Urology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London W6 8RF, UK.

Penny Flohr (P)

Division of Clinical Studies, The Institute of Cancer Research and Royal Marsden Hospital, Cotswold Road, Sutton SM2 5NG, UK.

Azeem Saleem (A)

Invicro, A Konica Minolta Company, Burlington Danes Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
Hull York Medical School, University of Hull, Cottingham Road, Hull HU6 7RX, UK.

Amit Bahl (A)

Department of Clinical Oncology, Bristol Haematology and Oncology Center, Horfield Road, Bristol BS2 8ED, UK.

Alison Falconer (A)

Department of Urology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London W6 8RF, UK.

Johann S De Bono (JS)

Division of Clinical Studies, The Institute of Cancer Research and Royal Marsden Hospital, Cotswold Road, Sutton SM2 5NG, UK.

Eric O Aboagye (EO)

Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
ORCID: 0000-0003-2276-6771

Stephen Mangar (S)

Department of Urology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London W6 8RF, UK.
ORCID: 0000-0002-3655-2830

Classifications MeSH