Abnormal Cholesterol Metabolism and Lysosomal Dysfunction Induce Age-Related Hearing Loss by Inhibiting mTORC1-TFEB-Dependent Autophagy.
age-related hearing loss
autophagy
hearing loss
lysosome biogenesis
mTORC1
transcription factor
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Dec 2023
15 Dec 2023
Historique:
received:
16
11
2023
revised:
07
12
2023
accepted:
12
12
2023
medline:
23
12
2023
pubmed:
23
12
2023
entrez:
23
12
2023
Statut:
epublish
Résumé
Cholesterol is a risk factor for age-related hearing loss (ARHL). However, the effect of cholesterol on the organ of Corti during the onset of ARHL is unclear. We established a mouse model for the ARHL group (24 months,
Identifiants
pubmed: 38139347
pii: ijms242417513
doi: 10.3390/ijms242417513
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : NRF-2019M3A9H1103737
Organisme : National Research Foundation of Korea
ID : NRF-2019R1A2C2002384