Synthesis, Antimalarial, Antileishmanial, and Cytotoxicity Activities and Preliminary In Silico ADMET Studies of 2-(7-Chloroquinolin-4-ylamino)ethyl Benzoate Derivatives.
ADMET
aminoalkylbenzoates
chloroquine
cytotoxicity
leishmaniasis
malaria
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
09 Dec 2023
09 Dec 2023
Historique:
received:
01
10
2023
revised:
20
11
2023
accepted:
29
11
2023
medline:
23
12
2023
pubmed:
23
12
2023
entrez:
23
12
2023
Statut:
epublish
Résumé
A series of heterocyclic chloroquine hybrids, containing a chain of two carbon atoms at position four of the quinolinic chain and acting as a link between quinoline and several benzoyl groups, is synthesized and screened in vitro as an inhibitor of β-hematin formation and in vivo for its antimalarial activity against chloroquine-sensitive strains of
Identifiants
pubmed: 38139835
pii: ph16121709
doi: 10.3390/ph16121709
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : The project was partially funded by Ministero del Poder Popular para Ciencias y Tecnología
ID : 028/2022, 055/2023
Organisme : Escuela de Medicina, Universidad de Especialidades Espíritu Santo (UEES)
ID : 2022-MED-001