Testing a Recombinant Form of Tetanus Toxoid as a Carrier Protein for Glycoconjugate Vaccines.

carrier protein glycoconjugate tetanus toxoid

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
28 Nov 2023
Historique:
received: 20 09 2023
revised: 07 11 2023
accepted: 23 11 2023
medline: 23 12 2023
pubmed: 23 12 2023
entrez: 23 12 2023
Statut: epublish

Résumé

Glycoconjugate vaccines play a major role in the prevention of infectious diseases worldwide, with significant impact on global health, enabling the polysaccharides to induce immunogenicity in infants and immunological memory. Tetanus toxoid (TT), a chemically detoxified bacterial toxin, is among the few carrier proteins used in licensed glycoconjugate vaccines. The recombinant full-length 8MTT was engineered in

Identifiants

pubmed: 38140177
pii: vaccines11121770
doi: 10.3390/vaccines11121770
pii:
doi:

Types de publication

Journal Article

Langues

eng

Auteurs

Davide Oldrini (D)

GSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.

Roberta Di Benedetto (R)

GSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.

Martina Carducci (M)

GSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.

Daniele De Simone (D)

GSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.

Luisa Massai (L)

GSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.

Renzo Alfini (R)

GSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.

Barbara Galli (B)

GSK, via Fiorentina 1, 53100 Siena, Italy.

Brunella Brunelli (B)

GSK, via Fiorentina 1, 53100 Siena, Italy.

Amanda Przedpelski (A)

Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Joseph T Barbieri (JT)

Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Omar Rossi (O)

GSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.

Carlo Giannelli (C)

GSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.

Rino Rappuoli (R)

Fondazione Biotecnopolo, via Fiorentina 1, 53100 Siena, Italy.

Francesco Berti (F)

GSK, via Fiorentina 1, 53100 Siena, Italy.

Francesca Micoli (F)

GSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.

Classifications MeSH