The depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. A prospective cohort study.
ARDS
Neuromuscular blockade
Respiratory mechanics
Train of four
Transpulmonary pressure
VILI
Journal
Journal of critical care
ISSN: 1557-8615
Titre abrégé: J Crit Care
Pays: United States
ID NLM: 8610642
Informations de publication
Date de publication:
22 Dec 2023
22 Dec 2023
Historique:
received:
17
04
2023
revised:
04
09
2023
accepted:
01
12
2023
medline:
24
12
2023
pubmed:
24
12
2023
entrez:
23
12
2023
Statut:
aheadofprint
Résumé
Data concerning the depth of neuromuscular blockade (NMB) required for effective relaxation of the respiratory muscles in ARDS are scarce. We hypothesised that complete versus partial NMB can modify respiratory mechanics. Prospective study to compare the respiratory mechanics of ARDS patients according to the NMB depth. Each patient was analysed at two times: deep NMB (facial train of four count (TOFC) = 0) and intermediate NMB (TOFC >0). The primary endpoint was the comparison of chest wall elastance (EL 33 ARDS patients were analysed. There was no statistical difference between the EL In ARDS, the relaxation of the respiratory muscles seems to be independent of the NMB level.
Sections du résumé
BACKGROUND
BACKGROUND
Data concerning the depth of neuromuscular blockade (NMB) required for effective relaxation of the respiratory muscles in ARDS are scarce. We hypothesised that complete versus partial NMB can modify respiratory mechanics.
METHOD
METHODS
Prospective study to compare the respiratory mechanics of ARDS patients according to the NMB depth. Each patient was analysed at two times: deep NMB (facial train of four count (TOFC) = 0) and intermediate NMB (TOFC >0). The primary endpoint was the comparison of chest wall elastance (EL
RESULTS
RESULTS
33 ARDS patients were analysed. There was no statistical difference between the EL
CONCLUSION
CONCLUSIONS
In ARDS, the relaxation of the respiratory muscles seems to be independent of the NMB level.
Identifiants
pubmed: 38141458
pii: S0883-9441(23)00254-X
doi: 10.1016/j.jcrc.2023.154505
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
154505Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no competing interests to declare.