The intramolecular S

Diterpenoids Intramolecule S(N)2 reaction Isodon Isodon amethystoides Tautomer

Journal

Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R

Informations de publication

Date de publication:
21 Dec 2023
Historique:
received: 25 10 2023
revised: 14 12 2023
accepted: 16 12 2023
medline: 24 12 2023
pubmed: 24 12 2023
entrez: 23 12 2023
Statut: aheadofprint

Résumé

As our ongoing searching for the bioactive natural terpenoids, nine ent-kauranoids (1-9), including three previously undescribed ones (1, 2, and 9), were isolated from the aerial parts of Isodon amethystoides. Their structures were elucidated on the basis of spectroscopic data analysis, including NMR, MS, and ECD. Compounds 1 and 2 were a pair of tautomeric compounds, which was confirmed by the HPLC analysis and low temperature NMR testing. The underlying mechanism of the tautomer was proposed as an intramolecular S

Identifiants

DOI: 10.1016/j.fitote.2023.105788 PMID: 38141880
pubmed: 38141880
pii: S0367-326X(23)00363-5
doi: 10.1016/j.fitote.2023.105788
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105788

Informations de copyright

Copyright © 2023. Published by Elsevier B.V.

Auteurs

Lan Wu (L)

Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of pharmacy, Anhui Medical University, Hefei 230032, PR China.

Ming Zhang (M)

Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of pharmacy, Anhui Medical University, Hefei 230032, PR China.

Liu Wen-Hu (L)

Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of pharmacy, Anhui Medical University, Hefei 230032, PR China.

Yan-Fang Chen (YF)

Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of pharmacy, Anhui Medical University, Hefei 230032, PR China.

Xiu-Wen Yin (XW)

Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of pharmacy, Anhui Medical University, Hefei 230032, PR China.

Zhengbin Han (Z)

Suzhou lvyuan Triditional Chinese Medicine Technology Co., Ltd., Suzhou 234000, PR China.

Fu-Cai Ren (FC)

Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of pharmacy, Anhui Medical University, Hefei 230032, PR China.

Xiang-Dong Pu (XD)

Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of pharmacy, Anhui Medical University, Hefei 230032, PR China.

Xin-Hua Liu (XH)

Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of pharmacy, Anhui Medical University, Hefei 230032, PR China.

Jing-Bo Shi (JB)

Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of pharmacy, Anhui Medical University, Hefei 230032, PR China. Electronic address: sjbo616@126.com.

Chuan-Pu Shen (CP)

Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of pharmacy, Anhui Medical University, Hefei 230032, PR China. Electronic address: shenchuanpu@126.com.

Classifications MeSH