Clinical outcome and peripheral immune profile of myasthenic crisis with omicron infections: A prospective cohort study.

Clinical outcome Interleukin-6 Myasthenic crisis Omicron infections Peripheral immune

Journal

Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537

Informations de publication

Date de publication:
22 Dec 2023
Historique:
received: 19 10 2023
revised: 28 11 2023
accepted: 19 12 2023
medline: 25 12 2023
pubmed: 25 12 2023
entrez: 24 12 2023
Statut: aheadofprint

Résumé

The impact of Omicron infections on the clinical outcome and immune responses of myasthenia gravis (MG) remained largely unknown. From a prospective multicenter MG cohort (n = 189) with 197 myasthenic crisis (MC), we finally included 41 independent MG patients to classify into two groups: the Omicron Group (n = 13) and the Control Group (n = 28). In this matched cohort study, all-cause mortality was 7.69% (1/13) in Omicron Group and 14.29% (4/28) in Control Group. A higher proportion of elevated serum IL-6 was identified in the Omicron Group (88.89% vs 52.38%, P = 0.049). In addition, the proportions of CD3

Identifiants

DOI: 10.1016/j.clim.2023.109879 PMID: 38142901
pubmed: 38142901
pii: S1521-6616(23)00643-5
doi: 10.1016/j.clim.2023.109879
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109879

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Xiao Huan (X)

Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai 200040, China.

Jialin Chen (J)

Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.

Huahua Zhong (H)

Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai 200040, China.

Yafang Xu (Y)

Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai 200040, China.

Yuan Wang (Y)

Department of Blood Transfusion, Huashan Hospital, Fudan University, Shanghai 200040, China.

Haoqin Jiang (H)

Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.

Jie Song (J)

Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai 200040, China.

Chong Yan (C)

Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai 200040, China.

Jianying Xi (J)

Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai 200040, China.

Zhangyu Zou (Z)

Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.

Jianming Zheng (J)

Department of Infectious Diseases, Huashan Hospital, National Medical Center for Infectious Diseases, Fudan University, Shanghai 200040, China.

Zhe Ruan (Z)

Department of Neurology, Tangdu Hospital, The Air Force Medical University, Xi'an 710000, China.

Song Tan (S)

Department of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.

Lijun Luo (L)

Department of Neurology, Wuhan No.1 Hospital, Wuhan 430030, China.

Sushan Luo (S)

Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai 200040, China. Electronic address: luosushan@fudan.edu.cn.

Chongbo Zhao (C)

Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai 200040, China. Electronic address: zhao_chongbo@fudan.edu.cn.

Li Zeng (L)

Department of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Sichuan, China.

Jie Yang (J)

Department of Neurology, Wuhan No.1 hospital, Wuhan, China.

Heng Li (H)

Department of Neurology, Central hospital affiliated to Shandong First Medical University, Jinan, China.

Song Yang (S)

Department of Neurology, Changzhou First hospital, Changzhou, China.

Yali Zhang (Y)

Department of Neurology, Inner Mongolia Medical University, Inner Mongolia, China.

Qing Ke (Q)

Department of Neurology, the first affiliated hospital, Zhejiang University School of Medicine, Hangzhou, China.

Classifications MeSH