Amelioration of Amyloid-β Induced Alzheimer's Disease by Bacopa monnieri through Modulation of Mitochondrial Dysfunction and GSK-3β/Wnt/β-Catenin Signaling.

Alzheimer's disease Bacopa monnieri GSK-3β Wnt/β-catenin signaling mitochondrial dysfunction

Journal

Molecular nutrition & food research

ISSN: 1613-4133

Titre abrégé: Mol Nutr Food Res

Pays: Germany

ID NLM: 101231818

Informations de publication

Date de publication:
24 Dec 2023

Historique:

revised: 21 09 2023

received: 20 04 2023

medline: 25 12 2023

pubmed: 25 12 2023

entrez: 24 12 2023

Statut: aheadofprint

Résumé

Alzheimer's disease (AD) is the most prevalent dementia, affecting a large number of populations. Despite being under scrutiny for decades, an effective therapeutic option is still not available. This study explores the therapeutic role of a nootropic herb Bacopa monnieri (BM) in AD-like pathological conditions produced by injecting preformed amyloid-β BM has been used in diet as a nootropic herb for several centuries. This study highlights the anti-Alzheimer activity of BM from the behavioral to the molecular level by modulating mitochondrial dysfunction, and GSK-3β mediates the Wnt/β-catenin signaling pathway.

Sections du résumé

BACKGROUND BACKGROUND

Alzheimer's disease (AD) is the most prevalent dementia, affecting a large number of populations. Despite being under scrutiny for decades, an effective therapeutic option is still not available.

METHODS AND RESULTS RESULTS

This study explores the therapeutic role of a nootropic herb Bacopa monnieri (BM) in AD-like pathological conditions produced by injecting preformed amyloid-β

CONCLUSION CONCLUSIONS

BM has been used in diet as a nootropic herb for several centuries. This study highlights the anti-Alzheimer activity of BM from the behavioral to the molecular level by modulating mitochondrial dysfunction, and GSK-3β mediates the Wnt/β-catenin signaling pathway.

Identifiants

DOI: 10.1002/mnfr.202300245 PMID: 38143280

pubmed: 38143280

doi: 10.1002/mnfr.202300245

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

e2300245

Subventions

Organisme : DBT

ID : BT/PR32907/MED/122/227/2019

Organisme : DBT

ID : BT/PR38493/TRM/120/465/2020

Organisme : Ministry of Science and Technology (Govt. of India)

Organisme : DBT-BUILDER-Level-III

ID : BT/INF/22/SP45382/2022

Organisme : DST-FIST-II to School of Life Sciences, JNU, New Delhi, India

Organisme : UGC-JRF

ID : 652/(SC) (CSIR-UGC NET Dec. 2016

Organisme : DST INSPRE

ID : DST/INSPIRE Fellowship/2018/IF180507

Informations de copyright

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