Subtypes of Dementia with Lewy Bodies: Clinical Features, Survival, and Apolipoprotein E Effect.
Alzheimer’s disease
Lewy bodies
dementia
genetic
survival
Journal
Journal of Alzheimer's disease reports
ISSN: 2542-4823
Titre abrégé: J Alzheimers Dis Rep
Pays: Netherlands
ID NLM: 101705500
Informations de publication
Date de publication:
2023
2023
Historique:
received:
11
07
2023
accepted:
01
11
2023
medline:
25
12
2023
pubmed:
25
12
2023
entrez:
25
12
2023
Statut:
epublish
Résumé
Dementia with Lewy bodies (DLB) is a progressive neurodegenerative disease with various clinical symptoms. Limited data have described the clinical subtypes of DLB. We aimed to compare clinical subtypes of DLB according to initial symptoms and to study the effect of Apolipoprotein E ( We included DLB patients classified into three groups based on initial symptoms: non-motor onset (cognitive and/or psychiatric) (NMO-DLB), motor onset (parkinsonism and/or gait disorders) (MO-DLB), and mixed onset (non-motor and motor symptoms) (MXO-DLB). Clinical and A total of 268 patients were included (NMO-DLB = 75%, MXO-DLB = 15.3%, MO-DLB = 9.7%). Visual hallucinations were more frequent ( Our study revealed a few differences between DLB clinical subtypes.
Sections du résumé
Background
UNASSIGNED
Dementia with Lewy bodies (DLB) is a progressive neurodegenerative disease with various clinical symptoms. Limited data have described the clinical subtypes of DLB.
Objective
UNASSIGNED
We aimed to compare clinical subtypes of DLB according to initial symptoms and to study the effect of Apolipoprotein E (
Methods
UNASSIGNED
We included DLB patients classified into three groups based on initial symptoms: non-motor onset (cognitive and/or psychiatric) (NMO-DLB), motor onset (parkinsonism and/or gait disorders) (MO-DLB), and mixed onset (non-motor and motor symptoms) (MXO-DLB). Clinical and
Results
UNASSIGNED
A total of 268 patients were included (NMO-DLB = 75%, MXO-DLB = 15.3%, MO-DLB = 9.7%). Visual hallucinations were more frequent (
Conclusions
UNASSIGNED
Our study revealed a few differences between DLB clinical subtypes.
Identifiants
pubmed: 38143772
doi: 10.3233/ADR-230064
pii: ADR230064
pmc: PMC10741894
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1277-1288Informations de copyright
© 2023 – The authors. Published by IOS Press.
Déclaration de conflit d'intérêts
The authors have no conflict of interest to report.