Presence of ectopic germinal center structures in autoimmune hepatitis.

Antibody-secreting cells Autoimmune hepatitis Germinal center

Journal

Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537

Informations de publication

Date de publication:
23 Dec 2023
Historique:
received: 11 09 2023
revised: 08 12 2023
accepted: 13 12 2023
medline: 26 12 2023
pubmed: 26 12 2023
entrez: 25 12 2023
Statut: aheadofprint

Résumé

Autoimmune tissues may contain ectopic germinal centers (EGCs). However, these structures have never been described in the liver of patients suffering from autoimmune hepatitis (AIH). We retrospectively reviewed histological features of 120 definite AIH cases, and found 10 cases harboring markers of EGCs. In these cases, CD21

Identifiants

DOI: 10.1016/j.clim.2023.109876 PMID: 38145857
pubmed: 38145857
pii: S1521-6616(23)00640-X
doi: 10.1016/j.clim.2023.109876
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109876

Informations de copyright

Copyright © 2023. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflict of interest.

Auteurs

B Huard (B)

T-RAIG, TIMC, University Grenoble-Alpes/CNRS UMR5525, La Tronche, France. Electronic address: bertrand.huard@univ-grenoble-alpes.fr.

Chemkhi Zeineb (C)

T-RAIG, TIMC, University Grenoble-Alpes/CNRS UMR5525, La Tronche, France.

D Giovannini (D)

T-RAIG, TIMC, University Grenoble-Alpes/CNRS UMR5525, La Tronche, France; Department of Anatomocytopathology, University Hospital, Grenoble, France. Electronic address: dgiovannini@chu-grenoble.fr.

M Barre (M)

T-RAIG, TIMC, University Grenoble-Alpes/CNRS UMR5525, La Tronche, France. Electronic address: manon.barre@univ-grenoble-alpes.fr.

A Baillet (A)

T-RAIG, TIMC, University Grenoble-Alpes/CNRS UMR5525, La Tronche, France; Department of Rhumatology, University Hospital, Grenoble, France. Electronic address: abaillet@chu-grenoble.fr.

D Cornec (D)

Lymphocyte B and Autoimmunity, INSERM, UMR 1227, Department of Rhumatology, Brest university, Brest, France. Electronic address: divi.cornec@chu-brest.fr.

K Harada (K)

Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan. Electronic address: kenichih@med.kanazawa-u.ac.jp.

N Sturm (N)

T-RAIG, TIMC, University Grenoble-Alpes/CNRS UMR5525, La Tronche, France; Department of Anatomocytopathology, University Hospital, Grenoble, France. Electronic address: nsturm@chu-grenoble.fr.

Classifications MeSH