Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel.

This study aimed to evaluate and better understand the potential impact that a layer of surrounding hydrogel (mimicking living tissue) can have on the drug release from PLGA microparticles. Ibuprofen-loaded microparticles were prepared with an emulsion solvent extraction/evaporation method. The drug loading was about 48%. The surface of the microparticles appeared initially smooth and non-porous. In contrast, the internal microstructure of the particles exhibited a continuous network of tiny pores. Ibuprofen release from

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© 2023 The Authors. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Juergen Siepmann reports financial support was provided by Interreg 2 Seas programme. Juergen Siepmann reports financial support was provided by 10.13039/501100008530European Regional Development Fund. Axel Zeitler reports financial support was provided by Interreg 2 Seas programme. Axel Zeitler reports financial support was provided by 10.13039/501100008530European Regional Development Fund. The Editor-in-Chief of the journal (Juergen Siepmann) is one of the co-authors of this article. Also, one of the guest editors of this special issue (Axel Zeitler) is one of the co-authors of this article. The manuscript has been subject to all of the journal's usual procedures, including peer review, which has been handled independently of the Editor-in-Chief and of the guest editor Axel Zeitler.