A Retrospective Cohort Study Evaluating the Safety and Efficacy of Sequential versus Concurrent Intrapleural Instillation of Tissue Plasminogen Activator and DNase for Pleural Infection.

We conducted a retrospective review of patients with pleural infection requiring intrapleural therapy at two tertiary referral centres. We included 84 (62.2%) and 51 (37.8%) patients who received sequential and concurrent intrapleural therapy, respectively. Patient demographics and clinical characteristics, including age, RAPID score, and percentage of pleural opacity on radiographs before intrapleural therapy, were similar in both groups. Treatment failure rates (defined by either in-hospital mortality, surgical intervention, or 30-day readmission for pleural infection) were 9.5% and 5.9% with sequential and concurrent intrapleural therapy, respectively ( Our study adds to the growing literature on the safety and efficacy of concurrent intrapleural therapy in pleural infection.

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Copyright © 2023 Ken Junyang Goh et al.

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The authors declare that they have no conflicts of interest.