The yeast-human coevolution: Fungal transition from passengers, colonizers, and invaders.
fungal evolution
host immunity
host-fungi interaction
mycobiota
trained immunity
Journal
WIREs mechanisms of disease
ISSN: 2692-9368
Titre abrégé: WIREs Mech Dis
Pays: United States
ID NLM: 9918227353306676
Informations de publication
Date de publication:
26 Dec 2023
26 Dec 2023
Historique:
revised:
06
12
2023
received:
19
05
2023
accepted:
07
12
2023
medline:
26
12
2023
pubmed:
26
12
2023
entrez:
26
12
2023
Statut:
aheadofprint
Résumé
Fungi are the cause of more than a billion infections in humans every year, although their interactions with the host are still neglected compared to bacteria. Major systemic fungal infections are very unusual in the healthy population, due to the long history of coevolution with the human host. Humans are routinely exposed to environmental fungi and can host a commensal mycobiota, which is increasingly considered as a key player in health and disease. Here, we review the current knowledge on host-fungi coevolution and the factors that regulate their interaction. On one hand, fungi have learned to survive and inhabit the host organisms as a natural ecosystem, on the other hand, the host immune system finely tunes the response toward fungi. In turn, recognition of fungi as commensals or pathogens regulates the host immune balance in health and disease. In the human gut ecosystem, yeasts provide a fingerprint of the transient microbiota. Their status as passengers or colonizers is related to the integrity of the gut barrier and the risk of multiple disorders. Thus, the study of this less known component of the microbiota could unravel the rules of the transition from passengers to colonizers and invaders, as well as their dependence on the innate component of the host's immune response. This article is categorized under: Infectious Diseases > Environmental Factors Immune System Diseases > Environmental Factors Infectious Diseases > Molecular and Cellular Physiology.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1639Subventions
Organisme : JPI HDHL-INTIMIC
ID : JTC-2017-7
Organisme : Joint Programming Initiative A healthy diet for a healthy life
ID : 529051018
Organisme : Regione Toscana
ID : G84I18000160002
Organisme : Italian Ministry of Agriculture, Food, and Forestry Policies (MiPAAF)
ID : DM 36954/7303/18
Informations de copyright
© 2023 The Authors. WIREs Mechanisms of Disease published by Wiley Periodicals LLC.
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