Regular moderate physical exercise decreases Glycan Age index of biological age and reduces inflammatory potential of Immunoglobulin G.
Aging biomarkers
Biological age
GlycanAge index
Glycosylation
Physical activity
Journal
Glycoconjugate journal
ISSN: 1573-4986
Titre abrégé: Glycoconj J
Pays: United States
ID NLM: 8603310
Informations de publication
Date de publication:
Feb 2024
Feb 2024
Historique:
received:
06
12
2023
accepted:
13
12
2023
revised:
06
12
2023
pubmed:
26
12
2023
medline:
26
12
2023
entrez:
26
12
2023
Statut:
ppublish
Résumé
Physical inactivity and obesity are growing concerns, negatively impacting the general population. Moderate physical activity is known to have a beneficial anti-inflammatory effect. N-glycosylation of immunoglobulin G (IgG) reflects changes in the inflammatory potential of IgG. In this study, GlycanAge index of biological age (GlycanAge), one of the first commercially used biomarkers of aging, was employed to assess effects of exercise intensity in three different groups of athletes: professional competing athletes, regularly moderate active individuals and newly involved recreational individuals, compared to the group of inactive individuals. GlycanAge was significantly lower in the active group compared to the inactive group (β = -7.437, p.adj = 7.85E-03), and nominally significant and increased in professional athletes compared to the active group (β = 7.546, p = 3.20E-02). Competing female athletes had significantly higher GlycanAge comparing to active females exercising moderately (β = 20.206, p.adj = 2.71E-02), while the latter had significantly lower GlycanAge when compared with the inactive counterparts (β = -9.762, p.adj = 4.68E-02). Regular, life-long moderate exercise has an anti-inflammatory effect in both female and male population, demonstrated by lower GlycanAge index, and it has great potential to mitigate growing issues related to obesity and a sedentary lifestyle, which are relentlessly increasing world-wide.
Identifiants
pubmed: 38147152
doi: 10.1007/s10719-023-10144-5
pii: 10.1007/s10719-023-10144-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
67-76Subventions
Organisme : European Structural and Investment Fund, Croatian National Centre of Competence in Molecular Diagnostics
ID : KK.01.2.2.03.0006
Organisme : European Research Council ERC-Synergy Grant "GlycanSwitch "
ID : #101071386
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2023. The Author(s).
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