Wound healing after therapy of oral potentially malignant disorders with a 445-nm semiconductor laser: a randomized clinical trial.
Diode laser
Leukoplakia
OPMD
OSCC
Oral precursor lesion
Oral squamous cell carcinoma
Oral surgery
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
26 Dec 2023
26 Dec 2023
Historique:
received:
18
09
2023
accepted:
18
11
2023
medline:
26
12
2023
pubmed:
26
12
2023
entrez:
26
12
2023
Statut:
epublish
Résumé
Oral potentially malignant disorders (OPMDs) are the most clinically relevant precursor lesions of the oral squamous cell carcinoma (OSCC). OSCC is one of the 15 most common cancers worldwide. OSCC is with its high rate of mortality an important cause of death worldwide. The diagnosis and therapy of clinically relevant precursor lesions of the OSCC is one of the main parts of prevention of this malignant disease. Targeted therapy is one of the main challenges concerning an oncologically safe tissue removal without overwhelming functional and aesthetic impairment. In this randomized controlled trial, a newly introduced intraoral 445-nm semiconductor laser (2W; cw-mode; SIROLaser Blue, Dentsply Sirona, Bensheim, Germany) was used in the therapy of OPMDs. Duration and course of wound healing, pain, and scar tissue formation were compared to classical cold blade removal with primary suture by measuring remaining wound area, tissue colorimetry, and visual analogue scale. The study includes 40 patients randomized using a random spreadsheet sequence in two groups (n1 = 20; n2 = 20). This comparative analysis revealed a significantly reduced remaining wound area after 1, 2, and 4 weeks in the laser group compared to the cold blade group (p < 0.05). In the laser group, a significantly reduced postoperative pain after 1 week was measured (p < 0.05). Laser coagulation of OPMDs with the investigated 445-nm semiconductor laser is a safe, gentle, and predictable surgical procedure with beneficial wound healing and reduced postoperative discomfort. Compared to the more invasive and bloody cold blade removal with scalpel, the 445-nm semiconductor laser could be a new functional less traumatic tool in the therapy of OPMDs. The method should be further investigated with regard to the identification of further possible indications. German Clinical Trials Register No: DRKS00032626.
Identifiants
pubmed: 38147181
doi: 10.1007/s00784-023-05438-9
pii: 10.1007/s00784-023-05438-9
doi:
Types de publication
Journal Article
Langues
eng
Pagination
26Informations de copyright
© 2023. The Author(s).
Références
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:E359–E386. https://doi.org/10.1002/ijc.29210
doi: 10.1002/ijc.29210
pubmed: 25220842
Kaatsch P, Spix C, Hentschel S, Katalinic A, Luttmann S, Stegmaier C, Caspritz S, Cernaj J, Ernst A, Folkerts J (2013) Krebs in Deutschland 2009/2010; 9. Ausgabe. Robert Koch-Institut (Hrsg) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. (Hrsg), Berlin
Sobin LH, Gospodarowicz MK, Wittekind C and International Union against Cancer (2010) TNM classification of malignant tumours. Wiley-Blackwell, Chichester, West Sussex, UK; Hoboken, NJ
Sobin LH, Wittekind C and International Union against Cancer (2002) TNM: classification of malignant tumours. Book title, 6th edn. Wiley-Liss, New York
Kämmerer PW, Morbach T, Schneider D, Liese J (2017) Diagnostik potenziell maligner Mundschleimhautveränderungen in der Zahnarztpraxis. wissen kompakt 11:105–120. https://doi.org/10.1007/s11838-017-0045-z
doi: 10.1007/s11838-017-0045-z
Niemz MH (2007) Laser-tissue interactions. Springer
doi: 10.1007/978-3-540-72192-5
Pick RM, Colvard MD (1993) Current status of lasers in soft tissue dental surgery. J Periodontol 64:589–602. https://doi.org/10.1902/jop.1993.64.7.589
doi: 10.1902/jop.1993.64.7.589
pubmed: 8366410
Arndt KA, Dover JS, Olbricht SM (1997) Lasers in cutaneous and aesthetic surgery. Lippincott-Raven Publishers, Philadelphia
Lenz H, Eichler J, Schafer G, Salk J, Bettges G (1977) Production of a nasoantral window with an Ar+-laser. J Maxillofac Surg 5:314–317
doi: 10.1016/S0301-0503(77)80125-2
pubmed: 271192
Braun A, Kettner M, Berthold M, Wenzler J-S, Heymann PGB, Frankenberger R (2018) Efficiency of soft tissue incision with a novel 445-nm semiconductor laser. Lasers Med Sci 33:27–33
doi: 10.1007/s10103-017-2320-9
pubmed: 28889322
Fornaini C, Rocca J-P, Merigo E (2016) 450 nm diode laser: a new help in oral surgery. World J Clin Cases 4:253
doi: 10.12998/wjcc.v4.i9.253
pubmed: 27672639
pmcid: 5018621
Reichelt J, Winter J, Meister J, Frentzen M, Kraus D (2017) A novel blue light laser system for surgical applications in dentistry: evaluation of specific laser-tissue interactions in monolayer cultures. Clin Oral Investig 21:985–994. https://doi.org/10.1007/s00784-016-1864-6
doi: 10.1007/s00784-016-1864-6
pubmed: 27251194
Dias SB, Fonseca MV, Dos Santos NC, Mathias IF, Martinho FC, Junior MS, Jardini MA, Santamaria MP (2015) Effect of GaAIAs low-level laser therapy on the healing of human palate mucosa after connective tissue graft harvesting: randomized clinical trial. Lasers Med Sci 30:1695–1702. https://doi.org/10.1007/s10103-014-1685-2
doi: 10.1007/s10103-014-1685-2
pubmed: 25373688
Knosel M, Attin R, Jung K, Brunner E, Kubein-Meesenburg D, Attin T (2009) Digital image color analysis compared to direct dental CIE colorimeter assessment under different ambient conditions. Am J Dent 22:67–72
pubmed: 19626967
Parker S, Anagnostaki E, Mylona V, Cronshaw M, Lynch E, Grootveld M (2020) Systematic review of post-surgical laser-assisted oral soft tissue outcomes using surgical wavelengths outside the 650–1350 nm optical window. Photobiomodul Photomed Laser Surg 38:591–606. https://doi.org/10.1089/photob.2020.4847
doi: 10.1089/photob.2020.4847
pubmed: 33026973
Gobbo M, Bussani R, Perinetti G, Rupel K, Bevilaqua L, Ottaviani G, Biasotto M (2017) Blue diode laser versus traditional infrared diode laser and quantic molecular resonance scalpel: clinical and histological findings after excisional biopsy of benign oral lesions. J Biomed Opt 22:121602. https://doi.org/10.1117/1.JBO.22.12.121602
doi: 10.1117/1.JBO.22.12.121602
pubmed: 28698889
Dawood MS, Salman SD (2013) Low level diode laser accelerates wound healing. Lasers Med Sci 28:941–945. https://doi.org/10.1007/s10103-012-1182-4
doi: 10.1007/s10103-012-1182-4
pubmed: 22895577
Fahimipour F, Mahdian M, Houshmand B, Asnaashari M, Sadrabadi AN, Farashah SE, Mousavifard SM, Khojasteh A (2013) The effect of He-Ne and Ga-Al-As laser light on the healing of hard palate mucosa of mice. Lasers Med Sci 28:93–100. https://doi.org/10.1007/s10103-012-1060-0
doi: 10.1007/s10103-012-1060-0
pubmed: 22415572
Serrage H, Heiskanen V, Palin WM, Cooper PR, Milward MR, Hadis M, Hamblin MR (2019) Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light. Photochem Photobiol Sci 18:1877–1909. https://doi.org/10.1039/c9pp00089e
doi: 10.1039/c9pp00089e
pubmed: 31183484
Noda M, Aoki A, Mizutani K, Lin T, Komaki M, Shibata S, Izumi Y (2016) High-frequency pulsed low-level diode laser therapy accelerates wound healing of tooth extraction socket: an in vivo study. Lasers Surg Med 48:955–964. https://doi.org/10.1002/lsm.22560
doi: 10.1002/lsm.22560
pubmed: 27454457
Enwemeka CS (2013) Antimicrobial blue light: an emerging alternative to antibiotics. Photomed Laser Surg 31:509–511. https://doi.org/10.1089/pho.2013.9871
doi: 10.1089/pho.2013.9871
pubmed: 24138170
Kim S, Kim J, Lim W, Jeon S, Kim O, Koh JT, Kim CS, Choi H, Kim O (2013) In vitro bactericidal effects of 625, 525, and 425 nm wavelength (red, green, and blue) light-emitting diode irradiation. Photomed Laser Surg 31:554–562. https://doi.org/10.1089/pho.2012.3343
doi: 10.1089/pho.2012.3343
pubmed: 24138193
pmcid: 3818000
Lipovsky A, Nitzan Y, Gedanken A, Lubart R (2010) Visible light-induced killing of bacteria as a function of wavelength: implication for wound healing. Lasers Surg Med 42:467–472. https://doi.org/10.1002/lsm.20948
doi: 10.1002/lsm.20948
pubmed: 20662022
Lopez-Jornet P, Camacho-Alonso F (2013) Comparison of pain and swelling after removal of oral leukoplakia with CO(2) laser and cold knife: a randomized clinical trial. Med Oral Patol Oral Cir Bucal 18:e38-44. https://doi.org/10.4317/medoral.17960
doi: 10.4317/medoral.17960
pubmed: 23229239
Rocca JP, Zhao M, Fornaini C, Tan L, Zhao Z, Merigo E (2018) Effect of laser irradiation on aphthae pain management: a four different wavelengths comparison. J Photochem Photobiol B 189:1–4. https://doi.org/10.1016/j.jphotobiol.2018.09.016
doi: 10.1016/j.jphotobiol.2018.09.016
pubmed: 30268950
Suter VGA, Sjolund S, Bornstein MM (2017) Effect of laser on pain relief and wound healing of recurrent aphthous stomatitis: a systematic review. Lasers Med Sci 32:953–963. https://doi.org/10.1007/s10103-017-2184-z
doi: 10.1007/s10103-017-2184-z
pubmed: 28345122
Genc Sen O, Kaya M (2019) Effect of Root Canal Disinfection with a Diode Laser on Postoperative Pain After Endodontic Retreatment. Photobiomodul Photomed Laser Surg 37:85–90. https://doi.org/10.1089/photob.2018.4539
doi: 10.1089/photob.2018.4539
pubmed: 31050927
Morsy DA, Negm M, Diab A, Ahmed G (2018) Postoperative pain and antibacterial effect of 980 nm diode laser versus conventional endodontic treatment in necrotic teeth with chronic periapical lesions: a randomized control trial. F1000Res 7:1795. https://doi.org/10.12688/f1000research.16794.1
doi: 10.12688/f1000research.16794.1
pubmed: 31372210
pmcid: 6659763
Arslan H, Doganay E, Karatas E, Unlu MA, Ahmed HMA (2017) Effect of low-level laser therapy on postoperative pain after root canal retreatment: a preliminary placebo-controlled, triple-blind, randomized clinical trial. J Endod 43:1765–1769. https://doi.org/10.1016/j.joen.2017.06.028
doi: 10.1016/j.joen.2017.06.028
pubmed: 28967495
Giovannacci I, Giunta G, Pedrazzi G, Meleti M, Manfredi M, Migliario M, Brucoli M, Greco Lucchina A, Mortellaro C, Vescovi P (2018) Erbium yttrium-aluminum-garnet laser versus traditional bur in the extraction of impacted mandibular third molars: analysis of intra- and postoperative differences. J Craniofac Surg 29:2282–2286. https://doi.org/10.1097/SCS.0000000000004574
doi: 10.1097/SCS.0000000000004574
pubmed: 29742567
Eshghpour M, Shaban B, Ahrari F, Erfanian M, Shadkam E (2017) Is low-level laser therapy effective for treatment of neurosensory deficits arising from sagittal split ramus osteotomy? J Oral Maxillofac Surg 75:2085–2090. https://doi.org/10.1016/j.joms.2017.04.004
doi: 10.1016/j.joms.2017.04.004
pubmed: 28495411
D'Avila RP, Espinola LVP, de Freitas PM, Silva AC, Landes C, Luz JGC (2019) Longitudinal evaluation of the effects of low-power laser phototherapy on mandibular movements, pain, and edema after orthognathic surgery. J Craniomaxillofac Surg 47:758–765. https://doi.org/10.1016/j.jcms.2019.01.038
doi: 10.1016/j.jcms.2019.01.038
pubmed: 30803856
Chatterjee P, Srivastava AK, Kumar DA, Chakrawarty A, Khan MA, Ambashtha AK, Kumar V, De Taboada L, Dey AB (2019) Effect of deep tissue laser therapy treatment on peripheral neuropathic pain in older adults with type 2 diabetes: a pilot randomized clinical trial. BMC Geriatr 19:218. https://doi.org/10.1186/s12877-019-1237-5
doi: 10.1186/s12877-019-1237-5
pubmed: 31405365
pmcid: 6689877
Anju M, Ummer VS, Maiya AG, Hande M (2019) Low level laser therapy for the patients with painful diabetic peripheral neuropathy - a systematic review. Diabetes Metab Syndr 13:2667–2670. https://doi.org/10.1016/j.dsx.2019.07.035
doi: 10.1016/j.dsx.2019.07.035
Cronshaw M, Parker S, Arany P (2019) Feeling the heat: evolutionary and microbial basis for the analgesic mechanisms of photobiomodulation therapy. Photobiomodul Photomed Laser Surg 37:517–526. https://doi.org/10.1089/photob.2019.4684
doi: 10.1089/photob.2019.4684
pubmed: 31329512
Pereira FC, Parisi JR, Maglioni CB, Machado GB, Barragan-Iglesias P, Silva JRT, Silva ML (2017) Antinociceptive effects of low-level laser therapy at 3 and 8 j/cm(2) in a rat model of postoperative pain: possible role of endogenous Opioids. Lasers Surg Med 49:844–851. https://doi.org/10.1002/lsm.22696
doi: 10.1002/lsm.22696
pubmed: 28671718
Cidral-Filho FJ, Mazzardo-Martins L, Martins DF, Santos AR (2014) Light-emitting diode therapy induces analgesia in a mouse model of postoperative pain through activation of peripheral opioid receptors and the L-arginine/nitric oxide pathway. Lasers Med Sci 29:695–702. https://doi.org/10.1007/s10103-013-1385-3
doi: 10.1007/s10103-013-1385-3
pubmed: 23832179
Matulic N, Bago I, Susic M, Gjorgievska E, KotaracKnezevic A, Gabric D (2019) Comparison of Er:YAG and Er, Cr:YSGG laser in the treatment of oral leukoplakia lesions refractory to the local retinoid therapy. Photobiomodul Photomed Laser Surg 37:362–368. https://doi.org/10.1089/photob.2018.4560
doi: 10.1089/photob.2018.4560
pubmed: 31081716
Schindl A, Schindl M, Pernerstorfer-Schon H, Schindl L (2000) Low-intensity laser therapy: a review. J investig Med 48:312–326
pubmed: 10979236
Cronshaw M, Parker S, Grootveld M and Lynch E (2023) Photothermal effects of high-energy photobiomodulation therapies: an in vitro investigation. Biomedicines 11. https://doi.org/10.3390/biomedicines11061634
Crippa R (2001) Report on 103 cases of precancerous and other oral lesions treated with a diode laser. J Oral Laser Appl 1:26
Suter VG, Altermatt HJ, Sendi P, Mettraux G and Bornstein MM (2010) CO2 and diode laser for excisional biopsies of oral mucosal lesions. A pilot study evaluating clinical and histopathological parameters. Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia 120:664–71
Deppe H, Mucke T, Hohlweg-Majert B, Hauck W, Wagenpfeil S, Holzle F (2012) Different CO2 laser vaporization protocols for the therapy of oral precancerous lesions and precancerous conditions: a 10-year follow-up. Lasers Med Sci 27:59–63. https://doi.org/10.1007/s10103-011-0910-5
doi: 10.1007/s10103-011-0910-5
pubmed: 21452010
Lauritano D, Lucchese A, Gabrione F, Di Stasio D, Silvestre Rangil J and Carinci F (2019) The effectiveness of laser-assisted surgical excision of leukoplakias and hyperkeratosis of oral mucosa: a case series in a group of patients. Int J Environ Res Public Health 16. https://doi.org/10.3390/ijerph16020210