Predictors of outcome in patients with moderate mixed aortic valve disease.

Grading the severity of moderate mixed aortic stenosis and regurgitation (MAVD) is challenging and the disease poorly understood. Identifying markers of haemodynamic severity will improve risk stratification and potentially guide timely treatment. This study aims to identify prognostic haemodynamic markers in patients with moderate MAVD. Moderate MAVD was defined as coexisting moderate aortic stenosis (aortic valve area (AVA) 1.0-1.5 cm 207 patients with moderate MAVD were included, aged 78 (66-84) years, 56% male sex, AVA 1.2 (1.1-1.4) cm Patients with truly moderate MAVD have a high incidence of death and heart failure hospitalisation (43% at 3.5 (2.5-4.7) years). Within this group, a high-risk group characterised by disproportionately low aortic Vmax (≤2.8 m/s) and adverse remodelling (LVEF ≤50%) have the worst outcomes.

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Déclaration de conflit d'intérêts

Competing interests: KPP has an unrestricted research grant from Edwards Lifesciences. TAT is directly and indirectly supported by the UCLH and Barts NIHR Biomedical Research Units. MJM has received grants and personal fees from Edwards Lifesciences and personal fees from Abbott Vascular.